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Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France

Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France

Journal of Hepatology 18(1): 119-122

The presence of mutants of the precore region of the hepatitis B virus genome was investigated in French patients with fulminant hepatitis. Only one of the 10 subjects had a detectable mutation by direct sequencing. On the other hand, 2/10 and 3/10 had evidence of coinfection by hepatitis D virus and hepatitis C virus. These results indicate that the precore stop mutation at codon 28 is not a general condition in fulminant hepatitis B and might reflect epidemiological factors.

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Accession: 008976168

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PMID: 8340604

DOI: 10.1016/s0168-8278(05)80019-4

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