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Manganese-dependent Dopa/tyrosine sulfation in HepG2 human hepatoma cells: Novel Dopa/tyrosine sulfotransferase activities associated with the human monoamine-form phenol sulfotransferase

Sakakibara, Y.; Katafuchi, J.; Takami, Y.; Nakayama, T.; Suiko, M.; Nakajima, H.; Liu, M.C.

Biochimica et Biophysica Acta 1355(2): 102-106

1997


ISSN/ISBN: 0006-3002
PMID: 9042329
DOI: 10.1016/s0167-4889(96)00166-8
Accession: 008990719

Human monoamine (M)-form phenol sulfotransferase (PST) was PCR-cloned and transiently expressed in COS-7 cells. The recombinant enzyme was demonstrated to display not only the previously reported sulfotransferase activity toward dopamine, but also novel manganese-dependent Dopa/tyrosine sulfotransferase activities. These results imply a new functional role of the human M-form PST in the homeostatic regulation of Dopa and tyrosine.

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