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Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin e receptor subtypes EP2 and EP3

Taketo, M.; Rochelle, J.M.; Sugimoto, Y.; Namba, T.; Honda, A.; Negishi, M.; Ichikawa, A.; Narumiya, S.; Seldin, M.F.

Genomics 19(3): 585-588

1994


ISSN/ISBN: 0888-7543
PMID: 7910583
DOI: 10.1006/geno.1994.1113
Accession: 008992168

Thromboxane A2 (TXA2) and prostaglandin E2 (PGE2) are two of the most representative eicosanoids that are formed from arachidonic acid. They produce a broad spectrum of biological effects mediated through specific cell surface receptors. We have mapped genetic loci for TXA2 receptor, Tbxa2r, and for PGE2 receptor subtypes EP2 and EP3, Ptgerep2 and Ptgerep3, respectively, using restriction fragment length variants in interspecific backcross mice. None of the three loci cosegregated with each other. Tbxa2r mapped to Chr 10, Ptgerep2 mapped to the distal end of Chr 3. Possible human loci for these receptors are predicted based on the homology between mouse and human chromosomes.

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