Methyl beta-carboline-3-carboxylate reverses the working memory deficits induced either by chronic alcohol consumption or mammillary body lesions in BALB/c mice
Beracochea, D.; Krazem, A.; Jaffard, R.
Psychobiology 23(1): 52-58
ISSN/ISBN: 0889-6313 DOI: 10.3758/bf03327058
This study showed that both chronic ethanol consumption and mammillary body (MB) lesions induced a trial-dependent sequential alternation deficit together with a reduction of anxiety-like reactions in an elevated plus maze and in an open field. The administration of beta-CCM (0.5 mg/kg, s.c.) increased anxiety-like reactions in all groups but significantly improved spontaneous alternation rates only in the alcohol group. However, increasing the dose of beta-CCM from 0.5 to 1.0 mg/kg also produced a memory-enhancing effect in MB-lesioned subjects. Taken together, this study shows that (1) memory deficits induced by chronic ethanol administration and MB lesions are reversed by beta-CCM administration and that (2) given the dose effects in MB mice, the MB could mediate, at least in part, the memory-enhancing effects of the drug.