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Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis

Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis

Journal of Virology 68(10): 6815-6819

Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced only slightly. By contrast, the mRNA levels of interleukin 1-beta, colony-stimulating factor 1 receptor, and tumor necrosis factor alpha increased following infection.

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Accession: 009035791

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PMID: 8084020

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