Molecular cloning and deduced primary structures of acidic and basic phospholipases A2 from the venom of Deinagkistrodon acutus

Wang, Y.M.; Wang, J.H.; Tsai, I.H.

Toxicon Official Journal of the International Society on Toxinology 34(10): 1191-1196


ISSN/ISBN: 0041-0101
PMID: 8931260
DOI: 10.1016/0041-0101(96)00067-0
Accession: 009042008

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This paper presents the nucleotide sequences of the cDNAs encoding three acidic phospholipases A-2 and one basic phospholipase A-2 from Deinagkistrodon acutus venom. The deduced primary structure of the basic enzyme is closest to that of the basic neurotoxic enzyme from Trimeresurus mucrosquamatus venom, while the acidic phospholipases from D. acutus have highest sequence similarity to that from Agkistrodon halys pallas. The phylogeny of this monotypic species is discussed.