EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript


Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript



Biochemical and Biophysical Research Communications 188(3): 1214-1219



ISSN/ISBN: 0006-291X

PMID: 1445355

DOI: 10.1016/0006-291x(92)91360-3

In the present study, we report the molecular cloning and sequence of an alternatively spliced form of the human thyrotropin receptor (hTSHR) mRNA transcript, which has previously been detected on Northern blot analysis of human thyroid cells. The smaller hTSHR cDNA, designated hTSHR cDNA-I, is approximately 1 kb in size and encodes a protein of 253 amino acids. Comparison of the nucleotide sequence of hTSHR cDNA-I with available hTSHR genomic sequence data reveals that the cDNA-I contains exons 1-98 and unidentified DNA tract, presumably an intron. Thus, the hTSHR cDNA-I encodes for the N-terminal half of the extracellular domain of the hTSHR (approximately 60%). The truncated TSHR-I may be secreted and function as a TSH binding protein.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009042623

Download citation: RISBibTeXText

Related references

An alternatively spliced form of the human thyrotropin receptor transcript. Nihon Rinsho. Japanese Journal of Clinical Medicine 52(4): 974-978, 1994

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Biochemical Journal 294: 373-380, 1993

Cloning of an alternatively spliced form of the human interferon alpha receptor. Journal of Interferon Research 12(Suppl 1): S220, 1992

Cloning and expression of a novel alternatively-spliced transcript for the glycosylphosphatidylinositol-anchored form of ceruloplasmin. Society for Neuroscience Abstracts 25(1-2): 2116, 1999

Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs. Annals of the new York Academy of Sciences 861: 234-235, 1998

Cloning and characterization of a novel alternatively spliced transcript of the human CHD7 putative helicase. Bmc Research Notes 3: 252, 2010

A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue. Molecular and Cellular Biology 10(6): 2973-2982, 1990

An alternatively spliced form of HLA-G mRNA in human trophoblasts and evidence for the presence of HLA-G transcript in adult lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 91(10): 4209-4213, 1994

An alternatively spliced transcript of the human Transferrin receptor gene. Biological Chemistry Hoppe-Seyler 376(SPEC Suppl ): S170, 1995

Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. Journal of Lipid Research 46(12): 2570-2579, 2005

Identification, cloning and analysis of expression of a new alternatively spliced form of the metabotropic glutamate receptor mGluR1 mRNA1. Biochimica et Biophysica Acta 1446(1-2): 161-166, 1999

Association of the glucocorticoid receptor alternatively-spliced transcript 1A with the presence of the high molecular weight membrane glucocorticoid receptor in mouse lymphoma cells. Journal of Cellular Biochemistry 74(3): 430-446, 1999

Cloning and characterization of 5'-end alternatively spliced human cholecystokinin-B receptor mRNAs. Receptors and Channels 6(3): 165-177, 1998

Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130. Febs Letters 412(2): 379-384, 1997

Molecular cloning and expression of two alternatively spliced human cyclin D-binding myb-like proteins. Proceedings of the American Association for Cancer Research Annual Meeting 41: 759, 2000