+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Morning fluoxetine plus evening mianserin versus morning fluoxetine plus evening placebo in the acute treatment of major depression

Morning fluoxetine plus evening mianserin versus morning fluoxetine plus evening placebo in the acute treatment of major depression

Pharmacopsychiatry 31(2): 48-54

In a randomized clinical study the combination of fluoxetine 20 mg daily and mianserin 30 mg daily was compared to fluoxetine 20 mg daily and a mianserin placebo. In total, 34 patients with major depression were randomized, of whom 16 received fluoxetine plus mianserin, 18 patients received fluoxetine plus placebo. Of these patients, 69% completed the planned trial of six weeks in the fluoxetine plus mianserin group while 61% completed in the fluoxetine plus placebo group. In the efficacy analysis (excluding dropouts from the first two weeks of treatment) the combination of fluoxetine and mianserin was superior to fluoxetine and placebo both in observer ratings of depression and in quality of life ratings. However, in the intention-to-treat analysis this difference was not statistically significant. No major side effects were reported. After four weeks of treatment headache was most often seen in the fluoxetine and mianserin combination, while sweating was most often seen in the fluoxetine plus placebo group. No pharmacokinetic interaction in terms of fluoxetine plasma levels was found in the mianserin-treated patients.

Accession: 009051534

Download citation: RISBibTeXText

PMID: 9562208

DOI: 10.1055/s-2007-979298

Related references

Efficacy and safety of morning versus evening fluoxetine administration. Journal of Clinical Psychiatry 52(3): 134-136, 1991

Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study. Bmj Open 6(2): E010313-E010313, 2016

Associations of depression and seasonality with morning-evening preference: Comparison of contributions of its morning and evening components. Psychiatry Research 262: 609-617, 2017

Double-blind randomized parallel-group clinical trial of efficacy of the combination fluoxetine plus modafinil versus fluoxetine plus placebo in the treatment of major depression. Depression and Anxiety 28(4): 297-302, 2011

Tretinoin gel microsphere pump 0.04% plus 5% benzoyl peroxide wash for treatment of acne vulgaris: morning/morning regimen is as effective and safe as morning/evening regimen. Journal of Drugs in Dermatology 9(7): 805-813, 2010

Influence of thyroid hormones on morning and evening TSH response to TRH in major depression. Biological Psychiatry. 35(12): 926-934, 1994

Benefits from mianserin augmentation of fluoxetine in patients with major depression non-responders to fluoxetine alone. Acta Psychiatrica Scandinavica 103(1): 66-72, January, 2001

Bright light treatment of winter depression: morning versus evening light. Acta Psychiatrica Scandinavica 82(5): 335-338, 1990

Can Levothyroxine Be Taken as Evening Dose? Comparative Evaluation of Morning versus Evening Dose of Levothyroxine in Treatment of Hypothyroidism. Journal of Thyroid Research 2011: 505239-505239, 2011

Morning vs evening light treatment of patients with winter depression. Archives of General Psychiatry 55(10): 890-896, 1998

Bambuterol in the treatment of asthma. A placebo-controlled comparison of once-daily morning vs evening administration. Chest 107(2): 406-412, 1995

Morning or evening bright light treatment of winter depression? The significance of hypersomnia. Biological Psychiatry 29(2): 117-126, 1991

The evening commute with cars and transit: Duality results and user equilibrium for the combined morning and evening peaks. Transportation Research Part B: Methodological 57: 286-299, 2013

The long-term effects of psychotherapy added to pharmacotherapy on morning to evening diurnal cortisol patterns in outpatients with major depression. PsychoTherapy and Psychosomatics 80(3): 166-172, 2011

Morning versus evening bright light treatment of late luteal phase dysphoric disorder. American Journal of Psychiatry 146(9): 1215-1217, 1989