+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Mortality from cancer of the male reproductive tract and environmental exposure to the anti-androgen p,p'-dichlorodiphenyldichloroethylene in the United States

Mortality from cancer of the male reproductive tract and environmental exposure to the anti-androgen p,p'-dichlorodiphenyldichloroethylene in the United States

Oncology 55(4): 334-339

The association of prostate cancer mortality and testicular cancer mortality with environmental exposure to the anti-androgen dichlorodiphenyltrichloroethane (DDT) derivative p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in the USA was explored in the period 1971-1994 using multiple linear regression analysis. Environmental p,p'-DDE contamination by state was estimated by p,p'-DDE concentrations in the subcutaneous fat of population samples and by measurements of p,p'-DDE in tree bark. On average, African Americans had adipose p,p'-DDE levels 74% higher than Whites (8.49 vs. 4.88 microg/g; p < 0.001). Neither prostate cancer mortality nor testicular cancer mortality showed a positive association with either indicator of p,p'-DDE environmental contamination. On the contrary, the regression coefficient for prostate cancer was constantly inverse for adipose p,p'-DDE along the period of study, although it approached statistical significance only for African Americans in 1981-1985 (P=-0.755; 0.10 > p > 0.05). This ecologic study does not provide support to the hypothesis of a link between environmental exposure to DDT derivatives and cancer of the male reproductive tract.

(PDF emailed within 0-6 h: $19.90)

Accession: 009055946

Download citation: RISBibTeXText

PMID: 9663423

DOI: 10.1159/000011872

Related references

Cancer mortality and environmental exposure to DDE in the United States. Environmental Health Perspectives 108(1): 1-4, 2000

Aquaporin 9 expression along the male reproductive tract Downregulation by the anti-androgen flutamide. FASEB Journal 15(4): A438, March 7, 2001

Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development. International Journal of Andrology 31(2): 178-187, 2008

Mortality risks associated with environmental tobacco smoke exposure in the United States. Nicotine & Tobacco Research 15(10): 1722-1728, 2014

Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young mice. Life Sciences 65(22): 2351-2357, Oct 22, 1999

Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen-oestrogen balance and assessment of the relevance to man. Human Reproduction Update 7(3): 236-247, 2001

Cancer mortality and environmental temperature in the United States. Lancet 1(7650): 766-768, 1970

In-hospital mortality after resection of biliary tract cancer in the United States. Hpb 12(1): 62-67, 2010

Environmental estrogens: roles in male reproductive tract problems and in breast cancer. Reviews on Environmental Health 17(4): 253-262, 2003

Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002. Bmc Cancer 6(): 264-264, 2006

Bladder cancer mortality in the United States, 1951-1989: increased environmental carcinogenesis in men. Regulatory Toxicology and Pharmacology 20(2): 187-197, 1994

Rising cancer mortality in the United States, 1962-1987: evidence against environmental causation. Regulatory Toxicology and Pharmacology 16(1): 81-92, 1992

Parity, other reproductive factors, and risk of pancreatic cancer mortality in a large cohort of U.S. women (United States). Cancer Causes & Control 16(9): 1035-1040, 2005