Home
  >  
Section 10
  >  
Chapter 9,062

Multiple domains for initiator binding proteins TFII-i and YY-1 are present in the initiator and upstream regions of the rat XDH/XO TATA-less promoter

Clark, M.P.; Chow, C.W.; Rinaldo, J.E.; Chalkley, R.

Nucleic Acids Research 26(11): 2813-2820

1998

ISSN/ISBN: 0305-1048
PMID: 9592172
DOI: 10.1093/nar/26.11.2813
Accession: 009061487
Download citation:  
Text
  |  
BibTeX
  |  
RIS
We previously reported that the TATA-less rat xanthine dehydrogenase/oxidase (XDH/XO) promoter is organized with multiple initiator elements (Inr 1, 2, 3 and 4). Additionally, we identified six factor binding footprints in the upstream region of this promoter (FP 1-FP 6), two of which (FP 2 and FP 4) we showed to be C/EBP binding sites. In this report we continue our characterization of the XDH/XO promoter, detailing other cis elements which comprise the Inr and upstream binding factors. Interestingly, multiple binding domains for known initiator binding proteins, YY-1 and USF-related factor/TFII-I, have been identified which potentially play an important role in transcription initiation.

PDF emailed within 0-6 h: $19.90




Related References

Johansson, E.; Skogman, E.; Thelander, L. 1995: The TATA-less promoter of mouse ribonucleotide reductase R1 gene contains a TFII-I binding initiator element essential for cell cycle-regulated transcription Journal of Biological Chemistry 270(50): 30162-30167
Weis, L.; Reinberg, D. 1997: Accurate positioning of RNA polymerase II on a natural TATA-less promoter is independent of TATA-binding-protein-associated factors and initiator-binding proteins Molecular and Cellular Biology 17(6): 2973-2984
Manzano Winkler, B.; Novina, C.D.; Roy, A.L. 1996: TFII is required for transcription of the naturally TATA-less but initiator-containing Vb promoter The Journal of Biological Chemistry 271: 076-81
Manzano-Winkler, B.; Novina, C.D.; Roy, A.L. 1996: TFII is required for transcription of the naturally TATA-less but initiator-containing Vbeta promoter Journal of Biological Chemistry 271(20): 12076-12081
Manzano-Winkler; Novina; Roy 1996: Additions and Corrections to TFII-I is required for transcription of the naturally TATA-less but initiator-containing Vbeta promoter Journal of Biological Chemistry 271(28): 16982
Gilinger, G.; Alwine, J.C. 1993: Transcriptional activation by simian virus 40 large T antigen: requirements for simple promoter structures containing either TATA or initiator elements with variable upstream factor binding sites Journal of Virology 67(11): 6682-6688
Martinez, E.; Chiang, C.M.; Ge, H.; Roeder, R.G. 1994: Tata-binding protein-associated factor(s) in Tfiid function through the initiator to direct basal transcription from a Tata-less class Ii promoter The Embo Journal 13(13): 3115-3126
Martinez, E.; Chiang, C.M.; Ge, H.; Roeder, R.G. 1994: TATA-binding protein-associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA-less class II promoter EMBO Journal 13(13): 3115-3126
Luo, H.; Gilinger, G.; Mukherjee, D.; Bellofatto, V. 1999: Transcription initiation at the TATA-less spliced leader RNA gene promoter requires at least two DNA-binding proteins and a tripartite architecture that includes an initiator element Journal of Biological Chemistry 274(45): 31947-31954
Morikawa, N.; Clarke, T.R.; Novina, C.D.; Watanabe, K.; Haqq, C.; Weiss, M.; Roy, A.L.; Donahoe, P.K. 2000: Human Müllerian-inhibiting substance promoter contains a functional TFII-I-binding initiator Biology of Reproduction 63(4): 1075-1083
Bogomolski-Yahalom, V.; Klein, A.; Greenblat, I.; Haviv, Y.; Tur-Kaspa, R. 1997: The TATA-less promoter of hepatitis B virus S gene contains a TBP binding site and an active initiator Virus Research 49(1): 1-7
Badran, B.M.; Kunstman, K.; Stanton, J.; Moschitta, M.; Zerghe, A.; Akl, H.; Burny, A.; Wolinsky, S.M.; Willard-Gallo, K.E. 2005: Transcriptional Regulation of the Human Cd3 Gene: The Tata-Less Cd3 Promoter Functions via an Initiator and Contiguous Sp-Binding Elements The Journal of Immunology 174(10): 6238-6249
Pérez Jurado, L.A.; Wang, Y.K.; Peoples, R.; Coloma, A.; Cruces, J.; Francke, U. 1998: A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-i and BAP-135, a phosphorylation target of BTK Human Molecular Genetics 7(3): 325-334
Geng, Y.; Johnson, L.F. 1993: Lack of an initiator element is responsible for multiple transcriptional initiation sites of the TATA-less mouse thymidylate synthase promoter Molecular and Cellular Biology 13(8): 4894-4903
Singh, U.; Rogers, J.B. 1998: The novel core promoter element GAAC in the hgl5 gene of Entamoeba histolytica is able to direct a transcription start site independent of TATA or initiator regions Journal of Biological Chemistry 273(34): 21663-21668