Muscimol-induced increase in dopamine release and metabolism is not observed in kainic acid-lesioned striatum of conscious rats: An in vivo microdialysis study
Yoshida, M.; Mizoguchi, K.; Yokoo, H.; Tanaka, T.; Ishii, H.; Emoto, H.; Koga, C.; Tanaka, M.
Neuroscience Letters 162(1-2): 5-8
ISSN/ISBN: 0304-3940 PMID: 8121635 DOI: 10.1016/0304-3940(93)90546-w
Local application of muscimol through the striatal dialysis membrane caused a significant increase in both dopamine release and dopamine metabolism in the striatum of conscious rats, however, both elevations induced by muscimol were significantly lower in the kainic acid-lesioned striatum when assessed with in vivo brain microdialysis. These findings show that intra-striatal muscimol indirectly stimulates nigrostriatal dopaminergic function by possibly causing an inhibition of striatal gamma-aminobutyric acid neurons.