Section 10
Chapter 9,065

Muscimol-induced increase in dopamine release and metabolism is not observed in kainic acid-lesioned striatum of conscious rats: An in vivo microdialysis study

Yoshida, M.; Mizoguchi, K.; Yokoo, H.; Tanaka, T.; Ishii, H.; Emoto, H.; Koga, C.; Tanaka, M.

Neuroscience Letters 162(1-2): 5-8


ISSN/ISBN: 0304-3940
PMID: 8121635
DOI: 10.1016/0304-3940(93)90546-w
Accession: 009064919

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Local application of muscimol through the striatal dialysis membrane caused a significant increase in both dopamine release and dopamine metabolism in the striatum of conscious rats, however, both elevations induced by muscimol were significantly lower in the kainic acid-lesioned striatum when assessed with in vivo brain microdialysis. These findings show that intra-striatal muscimol indirectly stimulates nigrostriatal dopaminergic function by possibly causing an inhibition of striatal gamma-aminobutyric acid neurons.

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