+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mutagenicity of bile and pancreatic juice from patients with pancreatico-biliary maljunction

Mutagenicity of bile and pancreatic juice from patients with pancreatico-biliary maljunction

Hepato-Gastroenterology 42(2): 113-116

We attempted to detect mutagenic activity in bile and pancreatic juice from patients with biliary tract disease using the spore rec assay and wild (H17) and mutant (M45) strains. Three bile samples out of 5 obtained from patients with pancreatico-biliary maljunction showed positive reaction in the spore rec assay, and all contained a high level of amylase activity, while 300 microliters of bile samples obtained from 10 control patients without pancreatico-biliary maljunction did not show any positive reaction. Moreover, 300 microliters of the in vitro mixture of bile with an equal volume of pancreatic juice also showed a positive reaction after treatment for 12 days at 37 degrees C or for 10 min at 100 degrees C, suggesting that they were very stable and long-acting in vivo. These data suggest that possible mutagens might be formed by the mixing of bile with pancreatic juice regurgitated into the biliary tract, and that there might be a relationship to biliary tract cancer which often accompanies pancreatico-biliary maljunction.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 009066153

Download citation: RISBibTeXText

PMID: 7545638

Related references

Pancreatico-biliary maljunction and congenital dilatation of bile duct. Nihon Geka Gakkai Zasshi 97(8): 589-593, 1996

Is spontaneous perforation of the bile duct in children due solely to pancreatico-biliary maljunction?. Pediatric Surgery International 18(5-6): 565-566, 2002

Does pancreatico-biliary maljunction play a role in spontaneous perforation of the bile duct in children?. Pediatric Surgery International 16(8): 550-553, 2000

Sonographic demonstration of wall thickness of the gallbladder in pediatric patients with pancreatico-biliary maljunction. Journal of Hepato-Biliary-Pancreatic Sciences 17(3): 345-348, 2010

Congenital biliary dilatation with pancreatico-biliary maljunction: a comparative study between children and adults. European Journal of Pediatric Surgery 4(1): 11-15, 1994

Modulation of pancreatic polypeptide secretion by pancreatico-biliary juice. Journal of Clinical Endocrinology and Metabolism 54(4): 831-836, 1982

Endoscopic repair of a massive postoperative pancreatic juice leak through the bile duct stump due to pancreatobiliary maljunction. Endoscopy 46 Suppl 1 Uctn: E165-E166, 2014

Adenosquamous carcinoma in a congenital choledochal cyst associated with pancreatico-biliary maljunction. Pathology International 59(7): 482-485, 2009

Activated pancreatic enzyme and pancreatic stone protein (PSP/reg) in bile of patients with pancreaticobiliary maljunction/ choledochal cysts. Digestive Diseases and Sciences 49(11-12): 1953-1956, 2005

The exclusion of bile pancreatic juice is more potent in enhancing cholecystokinin release and pancreatic exocrine secretion than summed effects of exclusions of bile and pancreatic juice in the conscious rats. Gastroenterology 94(5 Part 2): A321, 1988

Bile flow analysis by hepatobiliary scintigraphy in the terminal bile duct in patients with congenital malformations of the pancreatico-biliary ductal system. Gastroenterologia Japonica 26(2): 201-208, 1991

Entry of common bile and pancreatic ducts into a duodenal diverticulum cause of pancreatico biliary disease human inst cholangiography. Acta Paediatrica Suppl. 98(4): 447-450, 1969

A New Experimental Method To Obtain Bile And Pancreatic Juice In Dog. (Cannulation Of Chronic Internal Biliary And Pancreatic Fistulas). Medicina Experimentalis 10: 357-360, 1964

Biliary carcinoma risk in patients with pancreaticobiliary maljunction and the degree of extrahepatic bile duct dilatation. Hepato-Gastroenterology 53(72): 816-818, 2006

Potential diagnostic value of pancreatic isoamylases for pancreaticobiliary maljunction with mild biliary dilatation in patients and a porcine model. Journal of Pediatric Surgery 39(10): 1490-1494, 2004