+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes



Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes



Science 280(5370): 1750-1752



Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009066919

Download citation: RISBibTeXText

PMID: 9624052

DOI: 10.1126/science.280.5370.1750


Related references

Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression. Haematologica 93(12): 1822-1828, 2008

Hypermutation in Antibody Genes || In vivo and in vitro Studies of Immunoglobulin Gene Somatic Hypermutation. Philosophical Transactions Biological Sciences 356(1405): 21-28, 2001

Somatic mutation patterns in non-lymphoid cancers resemble the strand biased somatic hypermutation spectra of antibody genes. Dna Repair 9(6): 600-603, 2010

Hypermutation in Antibody Genes || Evolution and the Molecular Basis of Somatic Hypermutation of Antigen Receptor Genes. Philosophical Transactions Biological Sciences 356(1405): 67-72, 2001

The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process. Blood 103(9): 3490-3495, 2004

Clonal expansion, low-rate somatic hypermutation of rearranged immunoglobulin genes and V-gene replacement occur in monocytoid B cells and are independent of the germinal center. Blood 94(10 Suppl. 1 Part 2): 59b, 1999

Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase. Journal of Immunology 170(11): 5558-5562, 2003

Somatic hypermutation of Ig genes is affected differently by failures in apoptosis caused by disruption of Fas (lpr mutation) or by overexpression of Bcl-2. Scandinavian Journal of Immunology 63(6): 420-429, 2006

Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes. Dna Repair 5(11): 1384-1391, 2006

Hypermutation in Antibody Genes || A New Class of Errant DNA Polymerases Provides Candidates for Somatic Hypermutation. Philosophical Transactions Biological Sciences 356(1405): 47-51, 2001

Hypermutation in Antibody Genes || The Reverse Transcriptase Model of Somatic Hypermutation. Philosophical Transactions Biological Sciences 356(1405): 61-66, 2001

Hypermutation in Antibody Genes || Somatic Hypermutation and B-Cell Lymphoma. Philosophical Transactions Biological Sciences 356(1405): 73-82, 2001

Somatic hypermutation of VHS107 genes is not associated with gene conversion among family members. International Immunology 7(8): 1225-1235, 1995

Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?. Trends in Genetics 5(1): 4-8, 1989

Age-Associated B Cells Express a Diverse Repertoire of V H and Vκ Genes with Somatic Hypermutation. Journal of Immunology 198(5): 1921-1927, 2017