+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mutation of amino acids within the gibbon ape leukemia virus (GALV) receptor differentially affects feline leukemia virus subgroup B, simian sarcoma-associated virus, and GALV infections



Mutation of amino acids within the gibbon ape leukemia virus (GALV) receptor differentially affects feline leukemia virus subgroup B, simian sarcoma-associated virus, and GALV infections



Journal of Virology 67(11): 6737-6741



The three type C retroviruses, gibbon ape leukemia virus (GALV), simian sarcoma-associated virus (SSAV), and feline leukemia virus subgroup B (FeLV-B), infect human cells by interacting with the same cell surface receptor, GLVR1. Using LacZ retroviral pseudotypes and murine cells transfected with mutant GLVR1 expression vectors, we show that the same 9-amino-acid region of human GLVR1 is critical for infection by the three viruses.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 009066987

Download citation: RISBibTeXText

PMID: 8411376


Related references

Overexpression of gibbon ape leukemia virus (GALV) receptor (GLVR1) on human CD34(+) cells increases gene transfer mediated by GALV pseudotyped vectors. Molecular Therapy 6(3): 400-406, 2002

Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. Journal of Virology 66(2): 1219-1222, 1992

Multiple proteins interact with the gibbon ape leukemia virus galv enhancer element. Journal of Cellular Biochemistry Suppl. (13 Part B): 101, 1989

Chimeras of receptors for gibbon ape leukemia virus/feline leukemia virus B and amphotropic murine leukemia virus reveal different modes of receptor recognition by retrovirus. Journal of Virology 69(4): 2401-2405, 1995

Cis-acting transcriptional regulatory sequences in the gibbon ape leukemia virus (GALV) long terminal repeat. Virology 157(1): 211-219, 1987

Restricted expression of retrovirus nucleic acids and proteins in primate type C virus (gibbon ape leukemia virus-simian sarcoma virus)-initiated human B-lymphoblast cultures. Cancer Research 41(7): 2738-2744, 1981

Evaluation of captive gibbons (Hylobates spp., Nomascus spp., Symphalangus spp.) in North American Zoological Institutions for Gibbon Ape Leukemia Virus (GALV). Journal of Zoo and Wildlife Medicine 46(1): 27-33, 2015

Role of substance P (SP) and calcitonin gene-related peptide (CGRP) in gibbon-ape-leukemia virus (GALV) transduction of CD34+ cells. Neuropeptides 44(6): 491-494, 2010

Restricted expression of integrated primate type-C virus (gibbon ape leukemia virus-simian sarcoma virus) proviral DNA in nonproductively infected human B lymphoblasts. Virology 117(1): 195-206, 1982

Variable regions A and B in the envelope glycoproteins of feline leukemia virus subgroup B and amphotropic murine leukemia virus interact with discrete receptor domains. Journal of Virology 71(12): 9383-9391, 1997

Comparative restriction endonuclease maps of proviral DNA of the primate type C simian sarcoma-associated virus and gibbon ape leukemia virus group. Journal of Virology 41(1): 298-308, 1982

Simian sarcoma-associated virus fails to infect Chinese hamster cells despite the presence of functional gibbon ape leukemia virus receptors. Journal of Virology 72(12): 9453-9458, 1998

Studies on feline leukemia and sarcoma viruses. I. Characterization of monoclonal antibodies directed against the envelope proteins of feline leukemia virus. II. Isolation of a new transmissible feline sarcoma virus: NY-FESV. Dissertation Abstracts International, B 46(1): 71, 1985

Substitution of a single amino acid residue is sufficient to allow the human amphotropic murine leukemia virus receptor to also function as a gibbon ape leukemia virus receptor. Journal of Virology 70(2): 1080-1085, 1996

Effect of primate types c retroviruses gibbon ape leukemia virus and simian sarcoma virus infection on the in vitro growth and differentiation of fresh human b lymphocytes. Proceedings of the American Association for Cancer Research & American Society of Clinical Oncology 21: 312, 1980