+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Natural course of 500 consecutive cases of whooping cough: a general practice population study

Natural course of 500 consecutive cases of whooping cough: a general practice population study

BMJ 310(6975): 299-302

Objective: To describe the natural course of whooping cough. Design: Observational study of a general practice population. Setting: Discrete semirural East Midlands practice of 11500 patients. Subjects: 500 consecutive cases of whooping cough diagnosed clinically during 1977-92. Main outcome measures: Incidence of vomiting, whooping, apnoea, admission to hospital, and complications; duration and frequency of paroxysms. Pattern of spread. Results: The incidence in the practice population was 43.17/100000 population compared with a notification rate for England and Wales of 717/100000. Most cases were relatively mild. 284 patients vomited after paroxysms, 242 whooped, and 57 had apnoea. Duration and frequency of paroxysms varied widely. Female and unimmunised patients suffered more severe disease. Bordetella was isolated from fewer immunised patients (24/96 v 63/122 unimmunised). Infection was usually spread through contacts with someone with clinical whooping cough. Five patients developed pneumonia, three of whom had been immunised. Three patients required hospital admission. Conclusions: Most cases of whooping cough are relatively mild. Such cases are difficult to diagnose without a high index of suspicion because doctors are unlikely to hear the characteristic cough, which may be the only symptom. Parents can be reassured that a serious outcome is unlikely. Adults also get whooping cough, especially from their children, and get the same symptoms as children. The difficulty of early diagnosis and probability of missed cases reinforces the need to keep the incidence low through immunisation in order to protect infants, who are the most vulnerable.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 009077214

Download citation: RISBibTeXText

PMID: 7866173

Related references

Experiences with the anti-whopping cough drug P 150 Mack in general practice; with critical remarks on the etiology of whooping cough. Die Medizinische 20: 723-725, 1954

Occasional sporadic cases of whooping cough-like syndrome associated with adenoviral infection: contrast with epidemic whooping cough caused by Bordetella pertussis. Health Laboratory Science 8(4): 194-196, 1971

Cure of whooping cough and evolution of whooping cough mortality in hospitals: 1337 cases. La Semaine des Hopitaux 30(64/4): 3589-3594, 1954

Whooping cough in general practice. Bmj 333(7560): 159-160, 2006

Whooping-cough in general practice. Practitioner 180(1077): 350-353, 1958

The general practice management of whooping cough. Drugs 14(3): 220-222, 1977

Outbreak of whooping cough in general practice. British Medical Journal 2(6136): 577-578, 1978

Comparative evaluation on human subjects of immunizing properties of anti-whooping cough vaccines of domestic production. I. Laboratory evaluation of the whooping cough component in 3 diphteria-tetanus-whooping cough vaccines and serological reactions in vaccinated children. Przeglad Epidemiologiczny 15: 151-156, 1961

Bordetella pertussis isolation in general practice: 1977-79 whooping cough epidemic in West Glamorgan. Journal of Hygiene 90(2): 149-158, 1983

Experimental study of influenza-diphtheria-whooping cough vaccine. (Part II) Immunological reaction to diphtheria and whooping cough antigen. Voprosy Virusologii 5: 57-61, 1960

Study of an outbreak of whooping cough and measles in a rural community of the state of guerrero mexico test of a micro plate agglutination test for the diagnosis of whooping cough proposed by c. r. manclarck. Revista Latinoamericana de Microbiologia 25(1): 7, 1983

The Treatment of Whooping Cough with Staphylomycin. Study of 88 Cases. Therapie 18: 969-980, 1963

Whooping cough treated by staphylomycin. Study of 40 cases. Journal de Medecine de Bordeaux et du Sud-Ouest 143(2): 237-251, 1966

Whooping cough--a study of severity in hospital cases. Archives of Disease in Childhood 56(9): 687-691, 1981

Etiology of the whooping cough syndrome. Study of 50 cases. Gaceta Medica de Mexico 109(4): 245-251, 1975