Non-specific increase of serum carbohydrate antigen 19-9 in patients with liver disease associated with increased circulating levels of adhesion molecules

Fabris, C.; Falleti, E.; Pirisi, M.; Soardo, G.; Toniutto, P.; Vitulli, D.; Bortolotti, N.; Gonano, F.; Bartoli, E.

Clinica Chimica Acta; International Journal of Clinical Chemistry 243(1): 25-33


ISSN/ISBN: 0009-8981
PMID: 8747511
DOI: 10.1016/0009-8981(95)06150-9
Accession: 009103769

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Sialyl-Lewis-a antigen (SLe-a), the immune determinant of carbohydrate antigen 19-9 (CA 19-9), is the ligand of E-selectin. To verify the possibility of an association between nonspecific elevation of CA 19-9 and adhesion molecules, sera from 12 patients with acute hepatitis, 55 with non-cirrhotic chronic liver disease, 33 with cirrhosis and 25 with hepatocellular carcinoma, were tested for common liver function tests. Besides, CA 19-9 and soluble forms of E-selectin, VCAM-1 and ICAM-1 were measured immunoenzymatically. One-way analysis of variance demonstrated that mean CA 19-9 concentration differed among groups (F 15.27, P lt 0.0001) with the highest values found in patients with acute hepatitis. By univariate analysis, the strongest correlation of CA 19-9 was with soluble ICAM-1, which by stepwise multiple regression analysis was the only independent predictor of elevated CA 19-9 (multiple R 0.560). The association between ICAM-1 and CA 19-9 might originate in the biliary cells where they might be simultaneously overexpressed during inflammatory processes.