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Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells



Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells



Journal of Biological Chemistry 271(17): 10169-10174



Many amyloid diseases are characterized by protein aggregations linked to oxidative stress. Such diseases including those of the brain, muscle, and blood vessels exhibit plaques containing beta-amyloid (A-beta). Here we demonstrate that Alzheimer's precursor protein (beta-APP) and A-beta are present at low levels in normal lenses and increase in intact cultured monkey lenses treated with H-2O-2 or UV radiation (known cataractogenic agents), and with phorbol 12-myristate 13-acetate.

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Accession: 009147647

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PMID: 8626578

DOI: 10.1074/jbc.271.17.10169


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