+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

P53 overexpression in flat serrated adenomas and flat tubular adenomas of the colorectal mucosa



P53 overexpression in flat serrated adenomas and flat tubular adenomas of the colorectal mucosa



Journal Of Cancer Research & Clinical Oncology. 121(9-10): 571-576



The expression of the p53 protein was investigated in flat serrated neoplasias as well as in other histological phenotypes of flat or exophytic hyperplasias or neoplasias of the colorectal mucosa. A total of 104 such lesions were analyzed: 24 were flat serrated neoplasias (22 flat serrated adenomas and 2 flat serrated adenocarcinomas), 26 flat tubular adenomas, 17 flat hyperplastic polyps, 29 exophytic tubular and/or villous neoplasias (23 adenomas and 6 exophytic adenocarcinomas) and the remaining 8, exophytic hyperplastic polyps. Deparaffinized, rehydrated sections were treated immunohistochemically to detect those overexpressing the p53 protein. Lesions having slight (+), moderate (++) or intense (+++) staining were considered immunoreactive. The results showed that 50% of the flat serrated adenomas with low-grade dysplasia (LGD) and 66.7% of those with high-grade dysplasia (HGD) had p53 immunoreactivity. None of the flat tubular or of the exophytic adenomas with LGD expressed p53, but immunoreactivity was present in 61.5% of the flat tubular adenomas with HGD and in 52.3% of the exophytic adenomas with HGD. All adenocarcinomas had an intense p53 reaction. Weak p53 expression was demonstrated by 11.7% of the flat hyperplastic polyps but none of the exophytic polyps reacted. The occurrence of p53 expression in flat serrated adenomas with LGD suggested that, despite its low histological profile, one-half of those lesions could be biologically already committed to independent growth. The occurrence of p53 expression in nearly 12% of the flat hyperplastic polyps was totally unexpected and deserves further investigation. Flat serrated adenoma emerges as a novel, independent histological entity among the various phenotypes of flat neoplasias of the colorectal mucosa.

(PDF emailed within 0-6 h: $19.90)

Accession: 009150528

Download citation: RISBibTeXText

PMID: 7559739

DOI: 10.1007/bf01197772


Related references

Differences in the distribution of acidic mucins between flat tubular adenomas and flat serrated adenomas of the colorectal mucosa. In Vivo 10(3): 383-388, 1996

Flat serrated adenomas and flat tubular adenomas of the colorectal mucosa: differences in the pattern of cell proliferation. Japanese Journal of Cancer Research 86(8): 756-760, 1995

Flat serrated adenomas of the colorectal mucosa. Japanese Journal Of Cancer Research. 87(3): 305-309, 1996

Flat serrated adenomas of the colorectal mucosa in Japanese patients. In Vivo 10(3): 339-343, 1996

Flat adenomas and flat adenocarcinomas of the colorectal mucosa in Japanese and Swedish patients. Diseases of the Colon & Rectum 38(10): 1075-1079, 1995

Flat adenomas and flat adenocarcinomas of the colorectal mucosa in Japanese and Swedish patients. Comparative histologic study. Diseases of the Colon and Rectum 38(10): 1075-1079, 1995

Small flat adenomas and flat adenocarcinomas of the colorectal mucosa in Swedish and Japanese patients A comparative histological study. Pathology Research & Practice 191(7-8): 765-766, 1995

P53 overexpression in flat colorectal adenomas. Journal of Pathology 182(SUPPL ): 34A, 1997

P53 overexpression in polypoid versus flat colorectal adenomas. Gut 40(SUPPL 1): A47, 1997

"Are we ready to change our colorectal cancer screening practice?" Traditional serrated adenomas or serrated adenomas with dysplasia should be regarded as advanced adenomas with high grade dysplasia. Turkish Journal of Gastroenterology 27(5): 482-483, 2016

GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features. Histopathology 70(7): 1079-1088, 2017

Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas. Japanese Journal Of Cancer Research. 85(2): 147-151, 1994

An update on colorectal cancer pathology flat mucosal markers and flat adenomas in the lynch syndromes. Journal of Tumor Marker Oncology 5(3): 205, 1990

Differences in angiogenesis and collagenesis between exophytic and flat adenomas of the colorectal mucosa. Anticancer Research 17(1b): 737-742, 1997

Enhanced apoptosis in flat adenomas of the colorectal mucosa in Swedish and Japanese patients. Pathology Research & Practice 191(7-8): 766, 1995