+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Paired associate learning in the rat: Role of hippocampus, medial prefrontal cortex, and parietal cortex



Paired associate learning in the rat: Role of hippocampus, medial prefrontal cortex, and parietal cortex



Psychobiology 21(3): 183-192



Rats were tested for their ability to learn a list of four paired associates (food paired with spatial locations). In this task, rats display increased levels of correct orienting responses as a function of serial position of the paired associate within the list (temporal order function) when short intertrial intervals are used between paired associates. Furthermore, the rats are more likely to use intramaze rather than extramaze cues. These data suggest that rats utilize a temporal strategy to remember a list of paired associates. After training in this task, new rats received medial prefrontal cortex, hippocampus, parietal cortex, or cortical control lesions and were retested. The data indicate that rats with cortical control lesions continued to display a temporal order function, whereas rats with medial prefrontal cortex lesions showed a reduction in the number of correct orienting responses and failed to demonstrate the temporal order function, suggesting that the medial prefrontal cortex might mediate the selection of temporal strategies. Rats with hippocampal lesions also showed a marked reduction in level of correct orienting responses, but they continue to display a temporal order function, suggesting that these rats can still utilize a temporal strategy, but may have difficulties in remembering the appropriate paired associate items. Rats with parietal lesions did not display any significant changes in their temporal order function.

(PDF emailed within 0-6 h: $19.90)

Accession: 009153739

Download citation: RISBibTeXText

DOI: 10.3758/bf03327133


Related references

Dissociation of attention in learning and action: effects of lesions of the amygdala central nucleus, medial prefrontal cortex, and posterior parietal cortex. Behavioral Neuroscience 121(1): 63-79, 2007

The roles of the medial prefrontal cortex and hippocampus in a spatial paired-association task. Learning and Memory 15(5): 357-367, 2008

Parieto prefrontal connections in the monkey topographic distribution within the prefrontal cortex of sectors connected with the lateral and medial posterior parietal cortex. Society for Neuroscience Abstracts 11(1): 323, 1985

Comparisons of hemi-inattention produced by unilateral lesions of the posterior parietal cortex or medial agranular prefrontal cortex in rats: neglect, extinction, and the role of stimulus distance. Behavioural Brain Research 54(2): 117-131, 1993

Electrophysiological influences of the parietal cortex and dorso-medial thalamic nucleus on the prefrontal cortex of the cat. Experimental Physiology 77(2): 351-355, 1992

Glutamatergic or cholinergic stimulation of the medial prefrontal cortex increases acetylcholine release in the posterior parietal cortex. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 674 7, 2002

Activity in inferior parietal and medial prefrontal cortex signals the accumulation of evidence in a probability learning task. Plos Computational Biology 9(1): E1002895, 2013

Differential role of the dorsal hippocampus, ventro-intermediate hippocampus, and medial prefrontal cortex in updating the value of a spatial goal. Hippocampus 23(5): 342-351, 2013

Findings from animals concerning when interactions between perirhinal cortex, hippocampus and medial prefrontal cortex are necessary for recognition memory. Neuropsychologia 48(8): 2262-2272, 2010

Medial Orbitofrontal Cortex, Dorsolateral Prefrontal Cortex, and Hippocampus Differentially Represent the Event Saliency. Journal of Cognitive Neuroscience 2019: 1-11, 2019

Memory for duration: role of hippocampus and medial prefrontal cortex. Neurobiology of Learning and Memory 70(3): 328-348, 1998

Learning an operant conditioning task differentially induces gliogenesis in the medial prefrontal cortex and neurogenesis in the hippocampus. Plos One 6(2): E14713, 2011

Chronic stress induces persistent changes in global DNA methylation and gene expression in the medial prefrontal cortex, orbitofrontal cortex, and hippocampus. Neuroscience 322: 489-499, 2016

Memory for frequency in rats role of the hippocampus and medial prefrontal cortex. Behavioral & Neural Biology 53(3): 402-410, 1990

The role of the prefrontal and parietal cortex in learning and memory in monkeys. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 86(11): 1458-1470, 2001