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Partial characterization of the C-terminal non-collagenous domain (NC1) of collagen type X


Partial characterization of the C-terminal non-collagenous domain (NC1) of collagen type X



Biochemical Journal 320: 479-485



ISSN/ISBN: 0264-6021

PMID: 8973556

DOI: 10.1042/bj3200479

Collagen type X is composed of three identical alpha-1(X) chains of 59 kDa, each containing a triple-helical region of 45 kDa flanked by a short N-terminal sequence and a larger non-collagenous C-terminal (NC1) domain of approx. 15 kDa. Collagen type X molecules can associate via their C-termini to form a regular hexagonal lattice in vitro, which in vivo may provide a modified extracellular matrix for the events of endochondral ossification.

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Accession: 009159279

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