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Penetration of Sandimmune (cyclosporin A) in rat skin in vitro. Effects of penetration enhancers and solvents

Schmook, F.P.; Stütz, A.; Reinhardt, J.

Skin Pharmacology the Official Journal of the Skin Pharmacology Society 6(2): 116-124

1993

ISSN/ISBN: 1011-0283
PMID: 8352949
Accession: 009168247
The effect of various fatty acids or alcohols on the penetration rates and skin concentrations of cyclosporin A (Sandimmune; CyA) was evaluated in an in vitro model using skin of hairless rats. The influence of chain length, number and position of double bonds and branching of the carbon chain of the enhancer were investigated. In addition the penetration dependency of CyA on the concentration of both enhancer and CyA was studied. CyA was quantitated by high-performance liquid chromatography.

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Related References

Schmook, F P.; Stütz, A; Reinhardt, J 1993: Penetration of Sandimmune (Cyclosporin A) in Rat Skin in vitro Skin Pharmacology and Applied Skin Physiology 6(2): 116-124
Schmook, F.; Stutz, A.; Richter, F. 1990: The effect of structural variations of enhancers on sandimmune penetration in the in vitro rat skin model Journal of Investigative Dermatology 94(4): 576
Güngör, S.; Bergişadi, N. 2004: Effect of penetration enhancers on in vitro percutaneous penetration of nimesulide through rat skin Die Pharmazie 59(1): 39-41
Clarys, P.; Alewaeters, K.; Jadoul, A.; Barel, A.; Manadas, R.O.; Préat, V. 1998: In vitro percutaneous penetration through hairless rat skin: influence of temperature, vehicle and penetration enhancers European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 46(3): 279-283
Fincher, T.K.; Yoo, S.K.; SowellJ.W.Sr.; Michniak, B.B. 1996: In vitro percutaneous penetration enhancement of dideoxycytidine through hairless mouse skin using novel penetration enhancers Pharmaceutical Research (New York) 13(9 Suppl): S-373
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Cornwell, P.A.; Barry, B.W. 1993: The routes of penetration of ions and 5-fluorouracil across human skin and the mechanisms of action of terpene skin penetration enhancers International Journal of Pharmaceutics 94(1-3): 189-194
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Gabiga, H.; Cal, K.; Janicki, S. 2000: Effect of penetration enhancers on isosorbide dinitrate penetration through rat skin from a transdermal therapeutic system International Journal of Pharmaceutics 199(1): 1-6
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