Section 10
Chapter 9,169

Penetration of Sandimmune (cyclosporin A) in rat skin in vitro. Effects of penetration enhancers and solvents

Schmook, F.P.; Stütz, A.; Reinhardt, J.

Skin Pharmacology the Official Journal of the Skin Pharmacology Society 6(2): 116-124


ISSN/ISBN: 1011-0283
PMID: 8352949
Accession: 009168247

The effect of various fatty acids or alcohols on the penetration rates and skin concentrations of cyclosporin A (Sandimmune; CyA) was evaluated in an in vitro model using skin of hairless rats. The influence of chain length, number and position of double bonds and branching of the carbon chain of the enhancer were investigated. In addition the penetration dependency of CyA on the concentration of both enhancer and CyA was studied. CyA was quantitated by high-performance liquid chromatography.

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