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Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever

Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever

Antimicrobial Agents and ChemoTherapy 38(5): 1203-1204

Plasma penicillin levels were studied 2, 3, and 4 weeks after intramuscular benzathine penicillin G (BPG) doses of 1,200,000, 1,800,000, and 2,400,000 U. Proportions of patients with penicillin levels above 25 ng/ml at each week increased with increasing BPG dose. Further studies of higher-dose BPG for rheumatic fever prophylaxis are required.

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Accession: 009168427

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PMID: 8067767

DOI: 10.1128/aac.38.5.1203

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