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Pharmacokinetics of thiocolchicoside in humans using a specific radioimmunoassay


, : Pharmacokinetics of thiocolchicoside in humans using a specific radioimmunoassay. Therapeutic Drug Monitoring 17(5): 544-548

The myorelaxant thiocolchicoside (TC), an analogue of colchicine (COL), was assayed in plasma and urine by a radioimmunoassay (RIA) using a cross-reacting COL-specific polyclonal antibody. Cross-reactivity was 56% for TC, giving a limit of quantification of 0.5 ng/ml and a linear response from 0.5 to 100 ng/ml. Specificity was checked by cross-reactivity studies with COL analogues and by using liquid chromatography and RIA in tandem on urine samples. Two immunoreactive peaks were detected, but the nonspecific peak represented < 2% of the total urine concentration of TC. Pharmacokinetics of TC following infusion of 4 mg in two subjects revealed a moderate distribution (Vss from 31 to 35 L) and mainly extrarenal elimination (75% of the total body clearance). Terminal half-lives ranged from 2.4 to 2.7 h in plasma and from 3.2 to 3.7 h in urine.

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Accession: 009180986

PMID: 8585121

DOI: 10.1097/00007691-199510000-00018

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Other references

Preiskel, H., 1971: The canine teeth related to Bennett movement. British Dental Journal 131(7): 312-315

Head James W., 2000: Continental-scale glaciation and erosion on Mars; evidence for an extensive south polar ice cap in middle Mars history. The Dorsa Argentea Formation (Hd) forms south polar plains which embay older highland rocks. A second unit composed of rough massive deposits exposed in walls and floors of large irregular pits occurs largely surrounded by Hd. New MOLA altimetry d...

Zaman, A., 1988: Fertiliser management of safflower in laterite soils of West Bengal. In field trials in West Bengal during the rabi [dry] seasons of 1983-85, safflower cv. A-300 was given 0, 60 or 120 kg N, 0, 40 or 80 kg P2O5 and 0, 40, 80 or 120 kg K2O/ha. Seed yields were increased by all rates of N and by the lowest rates of P...

Geys J.F., 1989: Hemicidaroid echinoids from upper cretaceous deposits in the wadi qena area eastern desert egypt. A large number of regular echinoids has been collected by a German expedition in the Upper Cretaceous of Wadi Qena, Egypt. Five species belonging to the order Hemicidaroida are described and discussed in this paper. Hemicidaris bandeli is new. [Al...

Shields, E.D.; Altschuller, B.; Choi, E.Y.; Michaud, M., 1990: Odontometric variation among American black, European, and Mongoloid populations. Quantified dental parameters (including root and pulp areas and shape variables) derived from periapical radiographs were used to make comparisons among a sample of American Black (8 males--124 teeth, 9 females--138 teeth), European derivative (31...

Magni, P.; De Falco, G.; Como, S.; Casu, D.; Floris, A.; Petrov, A.N.; Castelli, A.; Perilli, A., 2008: Distribution and ecological relevance of fine sediments in organic-enriched lagoons: the case study of the Cabras lagoon (Sardinia, Italy). In organic-enriched sedimentary systems, like many Mediterranean coastal lagoons, a detailed analysis of sediment grain size composition and partitioning within the muds is crucial to investigate sedimentological trends related to both hydrodynami...

Efremov, Ilya A.; Christyakov, D. A.; Nosikov, V. V., 1996: Internal variations at the tetranucleotide tandem repeat HUMTH01 in a Russian population. European Journal of Human Genetics 4(SUPPL 1): 97

Hertz L., 1987: Benzodiazepine receptors in astrocytes. Grisar, Tl. (ed.). Advances In The Biosciences, Vol. 61. Dynamic Properties Of Glia Cells Ii: Cellular And Molecular Aspects; International Symposium, Liege, Belgium, May 12-15, . Xvii 424p. Pergamon Press: Oxford, England, Uk; New York, New York, Usa. Illus. 405-414, 1986

Fu P.; Zic V.; Gee K., 1975: Evaluation of automated bi chromatic immunoassay for specific proteins. Annals of Clinical & Laboratory Science 5(4): 310

Momany, M., 2002: Polarity in filamentous fungi: establishment, maintenance and new axes. Germ tube emergence in filamentous fungi appears to be similar to bud emergence in yeast. Several key proteins (e.g. Cdc42, septins, Bni1 formin, Rho1 and Rho3) play common roles in polarity establishment and early polarity maintenance in both pro...