+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Phencyclidine-like discriminative stimulus effects of polyamine modulators of N-methyl-D-aspartate receptor activity in rats



Phencyclidine-like discriminative stimulus effects of polyamine modulators of N-methyl-D-aspartate receptor activity in rats



Neuroscience Letters. 253(1): 53-56,. 28



Excessive N-methyl-D-aspartate (NMDA) receptor activation has been implicated in many acute and chronic neuropathologies. NMDA antagonists might prove to be useful treatments, unfortunately, some can produce phencyclidine (PCP)-like side effects. The polyamine-site modulators, spermine (SPM) and spermidine (SPD), produce dose related biphasic modulation of NMDA channel currents while another polyamine, arcaine (ARC), produces only negative modulatory effects. The PCP-like effects of these compounds were tested in rats trained to discriminate PCP from saline in a standard two-lever drug discrimination paradigm under a fixed ratio schedule of food reinforcement. SPM, SPD and ARC occasioned little, if any, responding on the PCP-associated lever, even at response rate suppressing doses. The results provide further evidence that differences exist between the discriminative stimulus effects produced by drugs active at different sites on the NMDA receptor and suggest that the polyamine modulatory site should be a good target for development of NMDA antagonist medications with a reduced propensity for PCP-like acute behavioral effects.

(PDF emailed within 0-6 h: $19.90)

Accession: 009184293

Download citation: RISBibTeXText

PMID: 9754803

DOI: 10.1016/s0304-3940(98)00606-5


Related references

The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats. Neuropharmacology 27(12): 1249-1256, 1988

Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma1 receptors. Behavioural Brain Research 119(1): 33-40, 15 February, 2001

The phencyclidine-like discriminative stimulus effects and reinforcing properties of the NR2B-selective N-methyl-D-aspartate antagonist CP-101 606 in rats and rhesus monkeys. Behavioural Pharmacology 18(8): 731-743, 2007

Interactions between N-methyl-D-aspartate receptor antagonists and the discriminative stimulus effects of morphine in rats. Pharmacology Biochemistry & Behavior. 60(2): 507-517, E, 1998

N-Methyl-D-aspartate receptor antagonists and the development of tolerance to the discriminative stimulus effects of morphine in rats. Journal of Pharmacology and Experimental Therapeutics 290(1): 20-27, 1999

Effects of N-methyl-D-aspartate receptor antagonists on discriminative stimulus effects of naloxone in morphine-dependent rats using the Y-maze drug discrimination paradigm. Journal of Pharmacology and Experimental Therapeutics 286(3): 1260-1268, 1998

Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-D-aspartate receptors?. Psychopharmacology 96(1): 87-92, 1988

The discriminative stimulus effects of MK-801: Generalization to other N-methyl-D-aspartate receptor antagonists. Journal of Psychopharmacology 3(4): 198-204, 1989

N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. Journal of Pharmacology and Experimental Therapeutics 352(1): 156-165, 2015

Dextro n allylnormetazocine nanm like discriminative stimulus effects of n methyl d aspartate nmda antagonists in rats. Society for Neuroscience Abstracts 15(2): 1167, 1989

Effects of strychnine-insensitive glycine receptor ligands on discriminative stimulus effects of N-methyl-D-aspartate channel antagonists. Society for Neuroscience Abstracts 18(1-2): 447, 1992

The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. Psychopharmacology 203(2): 441-451, 2009

Discriminative stimulus effects of site-selective N-methyl-D-aspartate antagonists in NPC 17742-trained rats and squirrel monkeys. Psychopharmacology. 132(4): 382-388, 1997

Discriminative stimulus effects of R- -3-amino-1-hydroxypyrrolid-2-one, , a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. Journal of Pharmacology & Experimental Therapeutics 275(3): 1267-1273, 1995

Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, ((+)-HA-966), a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. Journal of Pharmacology and Experimental Therapeutics 275(3): 1267-1273, 1995