EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Pinhole SPECT: an approach to in vivo high resolution SPECT imaging in small laboratory animals



Pinhole SPECT: an approach to in vivo high resolution SPECT imaging in small laboratory animals



Journal of Nuclear Medicine 35(2): 342-348



The performance of pinhole SPECT and the application of this technology to investigate the localization properties of radiopharmaceuticals in vivo in small laboratory animals are presented. Methods: System sensitivity and spatial resolution measurements of a rotating scintillation camera system are made for a low-energy pinhole collimator equipped with 1.0-, 2.0- and 3.3-mm aperture pinhole inserts. The spatial detail offered by pinhole SPECT for in vivo imaging was investigated in studies of the brain and heart in Fisher 344 rats by administering 201TlCl, 99mTc-HMPAO, 99mTc-DTPA and 99mTc-MIBI. Image acquisition is performed using a rotating scintillation camera equipped with a pinhole collimator; projection data are acquired in conventional step-and-shoot mode as the camera is rotated 360 degree around the subject. Pinhole SPECT images are reconstructed using a modified cone-beam algorithm developed from a two-dimensional fanbeam filtered backprojection algorithm. Results: The reconstructed transaxial resolution of 2.8 mm FWHM and system sensitivity of 0.086 c/s/kBq with the 2.0-mm pinhole collimator aperture provide excellent spatial detail and adequate sensitivity for imaging the regional uptake of the radiopharmaceuticals in tumor, organs and other tissues in small laboratory animals. Conclusion: The resolution properties of pinhole SPECT are superior to those which have been achieved thus far with conventional SPECT or PET imaging technologies. Pinhole SPECT provides an important approach for investigating localization properties of radiopharmaceuticals in vivo.

(PDF emailed within 1 workday: $29.90)

Accession: 009199376

Download citation: RISBibTeXText

PMID: 8295008



Related references

Less than 2 mm high resolution SPECT with pinhole collimator for small animals. Journal of Nuclear Medicine 34(5 SUPPL ): 194P, 1993

High resolution pinhole SPECT for small animal imaging. Journal of Nuclear Medicine 34(5 SUPPL ): 9P, 1993

Pinhole SPECT: ultra-high resolution imaging for small animal studies. Journal of Nuclear Medicine 36(12): 2287-2289, 1995

Design of rotating multi-pinhole SPECT system for high resolution small animal imaging. Journal of Nuclear Medicine 39(5 SUPPL ): 174P, 1998

Multi-pinhole collimator design for small-object imaging with SiliSPECT: a high-resolution SPECT. Physics in Medicine and Biology 54(2): 207-225, 2009

A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging. Brazilian Journal of Medical and Biological Research 43(12): 1160-1166, 2011

Application of an ultra high-resolution pinhole SPECT system based on a conventional camera for small animal imaging. Journal of Nuclear Medicine 42(5 Supplement): 54P-55P, 2001

Dynamic in vivo imaging of angiogenesis in CIA mouse-models using high-resolution multi-pinhole SPECT and a (99m)Tc-HYNIC-C-tagged VEGF. 2007

High resolution SPECT imaging for visualization of intratumoral heterogeneity using a SPECT/CT scanner dedicated for small animal imaging. Annals of Nuclear Medicine 26(1): 67-76, 2012

High resolution pinhole sequence imaging of small laboratory animals. Journal of Nuclear Medicine 32(5 SUPPL): 987, 1991

Design and performance of a multi-pinhole collimation device for small animal imaging with clinical SPECT and SPECT-CT scanners. Physics in Medicine and Biology 53(15): 4185-4201, 2008

High resolution pinhole SPECT for tumor imaging. Acta Oncologica (stockholm). 32(7-8): 861-867, 1993

High resolution PET, SPECT and projection imaging in small animals. Computerized Medical Imaging & Graphics 25(2): 79-86, March-April, 2001

An ECG-gated pinhole SPECT system for myocardial imaging of small animals. Journal of Nuclear Medicine 40(5 SUPPL ): 283P, 1999

High resolution SPECT imager for three-dimensional imaging of small animals. Journal of Nuclear Medicine 39(5 SUPPL ): 9P, 1998