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Platelet-derived endothelial cell growth factor: Pharmacokinetics, organ distribution and degradation after intravenous administration in rats



Platelet-derived endothelial cell growth factor: Pharmacokinetics, organ distribution and degradation after intravenous administration in rats



FEBS (Federation of European Biochemical Societies) Letters 313(2): 129-132



Platelet-derived endothelial cell growth factor (PD-ECGF) stimulates chemotaxis of endothelial cells in vitro and has angiogenic activity in vivo. Recently PD-ECGF was shown to have thymidine phosphorylase activity. In order to study possible therapeutic applications of PD-ECGF we used a rat model to determine its pharmacokinetics and tissue distribution after intravenous injection. [125I]PD-ECGF disappeared from the plasma in a biphasic manner, with estimated distribution and elimination half-lives of 17 min and 7 h, respectively. PD-ECGF was metabolized in the liver, excreted via the bile, and not accumulated in any organ system. The stability and long half-life in the circulation, together with the specificity for endothelial cells, suggest that PD-ECGF may be useful as a therapeutic agent to stimulate re-endothelialization in vivo, or, in view of its thymidine phosphorylase activity, in chemotherapy, by decreasing the pool of available thymidine.

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Accession: 009206347

Download citation: RISBibTeXText

PMID: 1426279

DOI: 10.1016/0014-5793(92)81428-o


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