Polymerase chain reaction detection of a novel human KIT (mast/stem cell growth factor receptor) gene polymorphism by single-strand conformation polymorphism analysis or by SmaI or BstNI cleavage

Spritz, R.A.; Holmes, S.A.

Human Genetics 92(2): 208-209

1993


ISSN/ISBN: 0340-6717
PMID: 7690341
DOI: 10.1007/bf00219695
Accession: 009210807

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Abstract
We describe a common single-base polymorphism of the KIT gene that alters both SmaI and BstNI restriction sites, but it most easily detected as a single-strand conformation polymorphism (SSCP) using the polymerase chain reaction (PCR).

Polymerase chain reaction detection of a novel human KIT (mast/stem cell growth factor receptor) gene polymorphism by single-strand conformation polymorphism analysis or by SmaI or BstNI cleavage