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Postantibiotic effect and postantibiotic effect of subinhibitory concentrations of quinolones against Pseudomonas aeruginosa


Epidemiologie Mikrobiologie Imunologie 45(2): 56-58
Postantibiotic effect and postantibiotic effect of subinhibitory concentrations of quinolones against Pseudomonas aeruginosa
The postantibiotic effect (PAE) (PA phase induced by 2 times or 4 times MIC) and postantibiotic effect of subinhibitory concentrations (PA SME) of three quinolones - enoxacin, norfloxacin and pefloxacin against Pseudomonas aeruginosa were determined. It was observed that the tested antibiotics at suprainhibitory concentrations 2 times MIC induced PAEs of 2.1-6.7 h. Longer PAEs were observed after treatment with antibiotics at concentration 4 times MIC (4.1-9.0 h). Subinhibitory concentrations of quinolones added to bacterial suspensions in the postantibiotic phase (2 times or 4 times MIC) displayed longer delay of bacterial regrowth (PA SMEs) compared to PAEs. No regrowth of bacterial culture was observed even at 48 h in the case of pefloxacin (2x MIC + 0.3x MIC, 4x MIC +0.2x MIC, 4x MIC + 0.3x AEC) as well as norfloxacin (4x MIC + 0.2x MIC, 4x MIC + 0.3x MIC).

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Accession: 009218531



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