Practical synthesis and regioselective alkylation of methyl-4(5)-(pentafluoroethyl)-2-propylimidazole-5(4)-carboxylate to give DuP 532, a potent angiotensin II antagonist

Practical synthesis and regioselective alkylation of methyl-4 - -2-propylimidazole-5 -carboxylate to give DuP 532, a potent angiotensin II antagonist. Journal of Organic Chemistry 58(17): 4642-4645, 1993

Regioselective N-Alkylation of Methyl Indole-2-carboxylate. Synthetic Communications 23(13): 1813-1820, 1993

Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, -1- ethyl 2-ethoxy-1- bipenyl-4-yl-methyl-1H-benzimidazole-7-carboxylate. Journal of Pharmacology & Experimental Therapeutics 268(3): 1540-1547, 1994

Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (+-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylate (TCV-116), in various hypertensive rats. Journal of Pharmacology and Experimental Therapeutics 268(3): 1540-1547, 1994

Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (racemic)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)bipenyl-4-yl)-methyl)-1H-benzimidazole-7-carboxylate (TCV-116), in various hypertensive rats. Journal of Pharmacology and Experimental Therapeutics 268(3): 1540-1547, 1994

Synthesis of KT3-671, 2-propyl-8-oxo-1 biphenyl-4-yl methyl-4,5,6,7-tetrahydro-cycloheptimidazole, a novel potent nonpeptide angiotensin II receptor antagonist. Journal of Labelled Compounds & Radiopharmaceuticals 36(10): 915-919, 1995

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116). Journal of Pharmacology and Experimental Therapeutics 266(1): 114-120, 1993

Synthesis of (14C)KT3-671, 2-propyl-8-oxo-1((2'-(1H-(14C) tetrazole-5-yl) biphenyl-4-yl) methyl)-4,5,6,7-tetrahydro-cycloheptimidazole, a novel potent nonpeptide angiotensin II receptor antagonist. Journal of Labelled Compounds and Radiopharmaceuticals 36(10): 915-919, 1995

Highly diastereoselective alkylation of aziridine-2-carboxylate esters: enantioselective synthesis of LFA-1 antagonist BIRT-377. Angewandte Chemie 44(38): 6169-6172, 2005

Regioselective dibromination of methyl indole-3-carboxylate and application in the synthesis of 5,6-dibromoindoles. Organic & Biomolecular Chemistry 9(14): 5021-5023, 2011

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-1H-benzimidazole-7-carboyxlic acid (CV-11974), and its prodrug, racemic-1-(cyclohexyloxycarbonyloxy)ethyl-2-ethoxy-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H benzimidazole-7-carboxylate (TCV-116). Journal of Pharmacology and Experimental Therapeutics 266(1): 114-120, 1993

Methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride A highly potent and selective 5-HT-4 receptor antagonist derived from metoclopramide. Journal of Medicinal Chemistry 36(25): 4121-4123, 1993

Regioselective C-H alkylation via carboxylate-directed hydroarylation in Water. Chemistry, 2018

Ro 15 1788 ethyl 8 fluoro 5 6 dihydro 5 methyl 6 oxo 4h imidazo 1 5 a 1 4 benzodiazepine 3 carboxylate is a potent antagonist of benzodiazepines in the olfactory cortex slice. Pfluegers Archiv European Journal of Physiology 396(4): 292-296, 1983

Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit. Bioorganic & Medicinal Chemistry Letters 20(6): 1854-1857, 2010