Preclinical pharmacology of the natural marine product dolastatin 10 (NSC 376128)
Newman, R.A.; Fuentes, A.; Covey, J.M.; Benvenuto, J.A.
Drug Metabolism and Disposition the Biological Fate of Chemicals 22(3): 428-432
ISSN/ISBN: 0090-9556 PMID: 8070319 Accession: 009225856
The preclinical pharmacology and pharmacokinetics of the natural marine product dolastatin 10 were investigated. Pharmacokinetics of (3H)dolastatin 10 were determined in CD2F1 mice after intravenous, subcutaneous, and intraperitoneal routes of administration. After intravenous injection (0.24 mg/kg), plasma drug concentration declined rapidly and was cleared from plasma with a half-life of 5.6 hr.