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Prenatal diagnosis, its potential impact on the prevalence and management of congenital anomalies



Prenatal diagnosis, its potential impact on the prevalence and management of congenital anomalies



Saudi Medical Journal 19(2): 130-135



Objective: To study the potential impact of prenatal diagnosis on the prevalence and pattern of major congenital anomalies, over a period of five years, at King Abudulaziz University Hospital, Jeddah. Setting: Fetal Medicine and Nursery Units. Subjects and method: All live born neonates admitted to the nursery with a diagnosis of congenital malformations as well as fetal anomalies diagnosed during prenatal ultrasound examination. Results: Among live born neonates, the prevalence of malformations was 1.83% (n=218). When cases diagnosed in the Fetal Medicine Unit were included, the figure went up to 2.0% (n=261). Anomalies of the CNS (26.9%) ranked first followed by CVS (16.0%), Chromosomal aberrations (12.4%), and other anomalies in variable order. Although the overall rate of fetal anomalies among our population was more or less similar to that published in similar studies, their pattern of distribution was different. Conclusion: Epidemiological studies on congenital malformation, based only on data from live born babies do not reflect either the true prevalence rate nor its distribution pattern in a given population. The value of prenatal diagnosis is no more confined to termination of affected pregnancies, but has an important role in planning the best circumstances for delivery that provide the optimum chance for fetal survival with minimal maternal morbidity.

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Accession: 009233507

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PMID: 27701571


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