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Prevalence of precore-defective mutant of hepatitis B virus in patients with hepatitis B in Shenyang



Prevalence of precore-defective mutant of hepatitis B virus in patients with hepatitis B in Shenyang



Journal of China Medical University 25(5): 505-507, 510



Sera from 70 patients with HBV infection were detected for HBV-DNA by nested-PCR. G-to-A mutants at 1896 sites on HBV preC region were tested positive by restriction fragment length polymorphism analysis. The findings were: (1) The positive rate of mutant on HBV preC region was 4%(1/25) in acute hepatitis, 25% (5/20) in chronic persistent hepatitis, 38% (5/13) in chronic active hepatitis, and 33% (4/12) in cirrhosis: (2). The positive rate of mutant on HBV preC region in patients with higher serum ALT level was 57% in HBeAg(-)/ant-HBe(-) group and 50% in HBeAg(-)/anti-HBe(+) group, and these were significantly higher than that in the patients with normal serum ALT level. Therefore, the results suggested that for the escape from host immunity, hepatitis B virus constantly made itself HBV-DNA variant which had to be involved in the mutant on HBV preC region of patients with chronic hepatitis.

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