+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Primary gastric lymphomas: Morphologic, immunohistochemical and immunogenetic analyses



Primary gastric lymphomas: Morphologic, immunohistochemical and immunogenetic analyses



Pathology International 46(9): 623-629



Morphologic, immunohistochemical and immunogenetic studies were performed on 28 cases of primary gastric lymphoma from fresh frozen tissue. Eight cases were diagnosed as diffuse large B-cell lymphoma, four as follicular center lymphoma (follicular), five as mucosa-associated lymphoid tissue (MALT) lymphoma, three as plasmacytoma, and three as T-cell lymphoma, two as mantle cell lymphoma, one as follicular center lymphoma (diffuse, predominantly small cell), and one as lymphoplasmacytold lymphoma, and one as Hodgkin's disease. From immunohistochemical studies, four types of morphologically similar low-grade lymphomas can be differentiated by a combination of various monoclonal antibodies. Cases of diffuse large B-cell lymphoma may have a germinal center origin. We observed lympho-epithelial lesions in cases of non-MALT lymphomas. We therefore consider that the current diagnostic criterion for MALT lymphoma may not always be valid. Except for cases of T-cell lymphoma and Hodgkin's disease, 17 out of 22 cases revealed clonal rearrangement bands of the JH gene. In situ hybridization (ISH) and polymerase chain reaction (PCR) studies revealed the presence of Epstein-Barr (EB) virus genomes in two and three cases, respectively. Epstein-Barr virus may play a role in lymphomagenesis, although on relatively rare occasions.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009244465

Download citation: RISBibTeXText

PMID: 8905870

DOI: 10.1111/j.1440-1827.1996.tb03664.x


Related references

Primary gastric Hodgkin's disease. Morphologic, immunohistochemical, and immunogenetic analyses. Archives of Pathology & Laboratory Medicine 119(2): 163-166, 1995

Immunohistochemical analyses of primary gastric lymphomas. Virchows Archiv 435(3): 242, 1999

Primary gastrointestinal malignant lymphomas. A morphologic and immunohistochemical study. Cancer 55(4): 870-879, 1985

Primary malignant lymphomas of the spleen. A morphologic and immunohistochemical analysis of 17 cases. Cancer 66(12): 2612-2619, 1990

Immunohistochemical analysis of p53 and bcl-2 in primary gastric non-Hodgkins lymphomas. Gut 37(Suppl. 1): A40, 1995

Morphologic and Immunohistochemical Appraisal of Primary Gastric Carcinomas. Applied Immunohistochemistry and Molecular Morphology 26(10): E107-E115, 2018

Vitiligo A morphologic, immunohistochemical, and molecular immunogenetic study. Journal of Cutaneous Pathology 23(1): 56, 1996

Co-expression of CD56 and CD30 in lymphomas with primary presentation in the skin: Clinicopathologic, immunohistochemical and molecular analyses of seven cases. Journal of Cutaneous Pathology 27(8): 392-399, 2000

Endocervical Adenocarcinoma With Morphologic Features of Both Usual and Gastric Types: Clinicopathologic and Immunohistochemical Analyses and High-risk HPV Detection by In Situ Hybridization. American Journal of Surgical Pathology 41(5): 696-705, 2017

Primary B-cell gastric lymphomas have two entities Immunohistochemical study and survival analysis. Gastroenterology. 110(4 Suppl.): A588, 1996

An immunohistochemical analysis of gastric B-cell lymphomas: Stromal cells exhibit peculiar histogenesis in gastric B-cell lymphomas. Acta Histochemica et Cytochemica 36(2): 153-164, 2003

Primary B-cell gastric lymphomas of mucosa-associated lymphoid tissue. Histological and immunohistochemical study of ten cases on surgical specimens. Histology and Histopathology 7(1): 129-136, 1992

Non-HTLV-1-associated primary gastric T-cell lymphomas show cytotoxic activity: Clinicopathological, immunohistochemical characteristics and TIA-1 expression in 31 cases. Histopathology 41(5): 421-436, 2002

Immunohistochemical and immunogenetic analyses of ocular adnexal lymphoid proliferation. Japanese Journal of Ophthalmology 44(4): 368-373, 2000

Non-Hodgkins lymphomas of the breast A morphologic and immunohistochemical evaluation. Laboratory Investigation 68(1): 84A, 1993