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Progesterone antagonists (Mifepristone and onapristone) and ovulation in rats and hamsters



Progesterone antagonists (Mifepristone and onapristone) and ovulation in rats and hamsters



Advances in Contraceptive Delivery Systems 9(2-3): 151-163



Administration of antiprogestagens RU486 and ZK299 to female cyclic rats results in blockade of ovulation. On the contrary, the antiprogestagens did not block the ovulatory process in the cyclic hamster, probably because RU486 and ZK299 have no affinity to the hamster progesterone receptor. Antiprogestagen-treated rats exhibit increased LH concentrations during the period of follicular development and increased testosterone/estradiol ratio.

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