+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic significance of serum antibodies to human papillomavirus-16 E4 and E7 peptides in cervical cancer



Prognostic significance of serum antibodies to human papillomavirus-16 E4 and E7 peptides in cervical cancer



Cancer 74(8): 2307-2313



Background: The objective of this study was to investigate the prognostic significance of serum antibodies to human papillomavirus (HPV)-16 peptides in patients with squamous cell cervical cancer. Methods: Pretreatment sera from 78 patients and 198 control women were tested by an enzyme-linked immunosorbent assay technique for reactivity with HPV-16 E4 (E401p) and E7 (E701p) synthetic peptides. The presence and serum level of these antibodies were correlated with tumor stage, histologic features. and prognostic parameters. Results: The median follow-up was 65 months (range, 6-97 months). Antibodies to E401p peptide were found in 5 of the 198 (3%) control subjects, 4 of the 43 (9%) patients with low tumor stage (International Federation of Gynecology and Obstetrics (FIGO) Ia, Ib, IIa), and 7 of the 35 (20%) patients with advanced tumor stage (FIGO IIb, III, IVa). Antibodies to E701p were found in 25 (13%), 11 (26%), and 11 (31%) women, respectively. The differences between patients and control subjects were significant (P lt 0.002). Seropositivity against these peptides showed no correlation with tumor stage. Antibody levels to both peptides were significantly higher in patients compared with control subjects (P lt 0.05). Furthermore, antibody levels to E401p were higher in patients with advanced tumor stage versus patients with low tumor stage (P = 0.0097). Such a relation was not found for anti-E701p antibodies. In the univariate analysis, a high level of anti-E701p antibodies was associated with a shorter disease free interval (P = 0.012) and poor survival (P = 0.049). However, this variable possessed no prognostic value after adjusting for FIGO stage and tumor size. Conclusions: The authors' findings indicate that the prognostic significance of serum antibodies to the HPV-16 E4 and E7 peptides used in this study of patients with cervical cancer is limited.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009254684

Download citation: RISBibTeXText

PMID: 7922982

DOI: 10.1002/1097-0142(19941015)74:8<2307::aid-cncr2820740815>3.0.co;2-x


Related references

Poster Radiotherapy Treatment in the Multidisciplinary Management of Endometrial Carcinomas: Institutional Experience and Results. European Journal of Cancer 47: S533-S534, 2011

Possible products at tooth amalgam interfaces. Journal of Dentistry 16(3): 140-144, 1988

Prognostic significance of human papillomavirus genomes and aberrant expression of p53 protein in human esophageal cancer. International Journal Of Cancer. 54(2): 226-230, 1993

Clinical significance of serum anti-annexin V antibodies in Egyptian patients with scleroderma. Egyptian Journal of Immunology 16(1): 1-8, 2009

Lessons Learned From the Womens Health Initiative Trials of Menopausal Hormone Therapy. Obstetrics and Gynecology 121(1): 172-176, 2013

Evaluation of antibodies to beta2-glycoprotein 1 in the causation of coronary atherosclerosis as part of the antiphospholipid syndrome. Australian and New Zealand Journal of Medicine 29(6): 789-793, 1999

Conium maculatum in Hedmark county, Eastern Norway. Blyttia 56(2): 92-93, 1998

Profiling of potential brassinosteroids in different tissues of rape flower by stable isotope labeling - liquid chromatography/mass spectrometry analysis. Analytica Chimica Acta 1037: 55-62, 2018

Human papillomavirus DNA and anti-HPV secretory IgA antibodies in cytologically normal cervical specimens. Journal Of Medical Virology. 43(2): 201-207, 1994

Antibodies to human myeloperoxidase in glomerular immune deposits of systemic lupus erythematosus. Lupus 9(8): 607-613, 2000

Prognostic significance of histopathological parameters in cancer of the larynx. European Archives of Oto-Rhino-Laryngology 256(3): 139-144, 1999

Prognostic significance of DNA index in advanced ovarian cancer. International Journal of Gynecological Cancer 1(5): 195-197, 1991

Occurrence of ichnofossils from the lateritic sediment of silai river section midnapur west bengal. Indian Journal of Earth Sciences 18(2): 146-147, 1991

Presence of antibodies to replication protein A in some patients with systemic lupus erythematosus (SLE). Clinical and Experimental Immunology 103(1): 74-76, 1996

Detection of human papillomavirus DNA on the fingers of patients with genital warts. Sexually Transmitted Infections 75(5): 317-319, 1999