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Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery

Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery

Ultrasound in Medicine and Biology 21(1): 41-47

ISSN/ISBN: 0301-5629

PMID: 7754578

DOI: 10.1016/0301-5629(94)00097-2

In vivo evaluation of Doppler contrast agent (DCA) enhancement has been principally qualitative. To quantitate the enhancement of the Doppler signal by perflubron emulsion, an investigational DCA, the audio-Doppler signal from the rabbit carotid artery was recorded during 0.5-ml/kg incremental doses to a total dose of 2.5 ml/kg. A representation of the recorded signal intensity, the Doppler power spectrum (DPS), was determined using a personal computer and commercially available software package. The dose related enhancement from perflubron emulsion was linear (r = 0.986, p = 0.0124) with a 710% (8.5 dB) overall enhancement at 2.5 ml/kg (p = 0.0001). Significant differences in enhancement could be detected with doses as low as 1.0 ml/kg and compared favorably with observer assessment of dose-related enhancement. This relatively simple method of computer analysis can quantify in vivo Doppler signal intensity and enhancement by perflubron emulsion and may enable quantitative comparisons between different DCAs.

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Accession: 009284382

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