+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

RNA-protein interactions in the regulation of coronavirus RNA replication and transcription



RNA-protein interactions in the regulation of coronavirus RNA replication and transcription



Biological Chemistry 378(6): 477-481



Coronavirus, with a 31-kb RNA genome, replicates its own RNA and transcribes subgenomic mRNAs by complex mechanisms. Viral RNA synthesis is regulated by multiple RNA regions, which appear to interact either directly or indirectly. Multiple cellular proteins bind to these regions and may undergo additional protein-protein interactions. These findings suggest that coronavirus RNA synthesis is carried out on a ribonucleoprotein via a mechanism that involves both viral and cellular proteins associated with viral RNA, similar to DNA-dependent RNA transcription. This mode of RNA synthesis may be applicable to most RNA viruses.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 009290713

Download citation: RISBibTeXText

PMID: 9224926


Related references

RNA-Pt adducts following cisplatin treatment of Saccharomyces cerevisiae. Acs Chemical Biology 7(1): 218-225, 2012

Regulation of coronary myoplasmic Ca(2+)-myosin light chain phosphorylation pathway and vasomotor tone: hyperpolarizing versus depolarizing cardioplegia. Surgery 128(2): 185-191, 2000

Host preferences of malaria mosquitoes are reflected in the responses of their olfactory cells to odours. Wiadomosci Parazytologiczne 44(4): 755, 1998

In situ-synthesized cadmium sulfide nanowire photosensor with a parylene passivation layer for chemiluminescent immunoassays. Biosensors and Bioelectronics 92: 221-228, 2017

The coronavirus nucleocapsid is a multifunctional protein. Viruses 6(8): 2991-3018, 2014

The SARS-associated stigma of SARS victims in the post-SARS era of Hong Kong. Qualitative Health Research 18(6): 729-738, 2008

Mechanism of coronary vasodilation produced by bradykinin. Circulation 83(6): 2048-2056, 1991

Regulation of DNA methylation of Rasgrf1. Nature Genetics 30(1): 92-96, 2002

Cytomegalovirus UL13 Controls Virion and Dense Body Egress. 2011

Coronavirus virulence genes with main focus on SARS-CoV envelope gene. Virus Research 194: 124-137, 2014

The role of replication proteins in the regulation of bacteriophage T4 transcription. I. Gene 45 and hydroxymethyl-C-containing DNA. Journal of Molecular Biology 96(4): 513-538, 1975

Identification of the target cells and sequence of infection during experimental infection of ovine fetuses with Cache Valley virus. Journal of Virology 86(9): 4793-4800, 2012

Replication and transcription of mammalian mitochondrial dna. Federation Proceedings 44(4): 1050, 1985

Reciprocal regulation of tissue-type and urokinase-type plasminogen activators in the differentiation of murine preadipocyte line 3T3-L1 and the hormonal regulation of fibrinolytic factors in the mature adipocytes. Journal of Cellular Physiology 189(1): 72-78, 2001

Interactions between coniothyrium minitans and sclerotia. Mycological Research 95(3): 295-299, 1991