+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Recognition of vaccinia virus-encoded major histocompatibility complex class I antigens by virus immune cytotoxic T cells is independent of the polymorphism of the peptide transporters



Recognition of vaccinia virus-encoded major histocompatibility complex class I antigens by virus immune cytotoxic T cells is independent of the polymorphism of the peptide transporters



Proceedings of the National Academy of Sciences of the United States of America 90(7): 2676-2680



In the cytotoxic T-cell response to viruses, peptide antigens of cytoplasmic origin are presented at the cell surface by the highly polymorphic major histocompatibility complex (MHC) class I molecules to CD8+ T-lymphocyte receptors. Peptide transporter molecules and other MHC-linked gene products have been implicated in the generation and import of antigenic peptides into the lumen of the endoplasmic reticulum for assembly with MHC class I glycoproteins. These accessory molecules in the antigen-presentation pathway map to a polymorphic region in the class II MHC, and the possibility of their allele-specific selectivity in antigen presentation has been raised. Here we show that additional, functionally polymorphic components are not apparent in an in vitro mouse MHC class I-restricted cytotoxic T-cell response to vaccinia and influenza viruses. When the mouse H-2K-d molecule was expressed via a recombinant vaccinia virus in target cells of different mouse MHC haplotypes or cells of rat, Syrian hamster, monkey, and human origin, efficient K-d-restricted and vaccinia virus-specific lysis was observed as measured with bulk effectors and at the clonal level. In addition, human transporters efficiently processed peptides originating from influenza virus nucleoprotein and hemagglutinin antigens as recognized by mouse influenza immune cytotoxic T cells.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009306540

Download citation: RISBibTeXText

PMID: 8464875

DOI: 10.2307/2361600


Related references

Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer. Proceedings of the National Academy of Sciences of the United States of America 95(17): 10112-6, 1998

Recognition by major histocompatibility complex class I-restricted cytolytic T lymphocytes of cells expressing vaccinia-encoded viral and class I proteins. European Journal of Immunology 17(10): 1515-1518, 1987

Association of mouse major histocompatibility and Rauscher murine leukaemia virus envelope glycoprotein antigens on leukaemia cells and their recognition by syngeneic virus-immune-cytotoxic T-lymphocytes. Scandinavian Journal of Immunology 8(6): 497-508, 1978

Class I major histocompatibility complex-restricted cytotoxic T cell responses to vaccinia virus in humans. Journal of General Virology 74: 751-754, 1993

Vaccinia virus decreases major histocompatibility complex (MHC) class II antigen presentation, T-cell priming, and peptide association with MHC class II. Immunology 128(3): 381-392, 2010

The Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the exocytic and endocytic pathways. Journal of Virology 85(4): 1604-1614, 2011

Major histocompatibility complex-encoded ABC transporters and rat class I peptide motifs. Transplantation Proceedings 25(5): 2752-2753, 1993

Neonatal tolerance of major histocompatibility complex antigens alters Ir gene control of the cytotoxic T cell response to vaccinia virus. Journal of Experimental Medicine 157(4): 1324-1338, 1983

Virus-immune cytotoxic T cells are sentized to by virus specifically altered structures coded for in H-2K or H-2D: a biological role for major histocompatibility antigens. Advances in Experimental Medicine and Biology 66: 387-389, 1976

The role of major histocompatibility complex and non-major histocompatibility complex encoded antigens in generation of bile duct lesions during hepatic graft-vs.-host responses mediated by helper or cytotoxic T cells. Hepatology 19(4): 980-988, 1994

Major histocompatibility complex class I-restricted presentation of influenza virus nucleoprotein peptide by B lymphoma cells harboring an antibody gene antigenized with the virus peptide. European Journal of Immunology 25(3): 776-783, 1995

Expression of major histocompatibility complex class I antigens as a strategy for the potentiation of immune recognition of tumor cells. Proceedings of the National Academy of Sciences of the United States of America 83(22): 8723-8727, 1986

Control of a virus infection of the mouse by cytotoxic t lymphocytes ctl after loss of the major histocompatibility complex encoded class i molecule that presents the immunodominant viral ctl epitope. Immunobiology 183(3-4): 165, 1991

Diverse peptide presentation of rhesus macaque major histocompatibility complex class I Mamu-A 02 revealed by two peptide complex structures and insights into immune escape of simian immunodeficiency virus. Journal of Virology 85(14): 7372-7383, 2011