+ Translate

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

, : Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes & Cancer 18(1): 59-65

Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%), 8p (65%), 16q (54%), 17p (51%), 13q and 6q (37% each), and 1p (30%). The most frequent gains occurred on 8q (60%), 1q (58%), and 6p and 17q (33% each). In a few cases, sequence amplifications were detected that were mapped to bands 11q12, 12p11, 14q12, and 19q13.1. This study represents the first analysis of primary liver cancers by CGH, and it confirms the presence of previously known chromosomal aberrations in HCC and highlights new quantitative abnormalities and sequence amplifications. These findings should lead to the characterization of new loci involved in liver cancer pathogenesis.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 009310320

PMID: 8993981

DOI: 10.1016/s0165-4608(97)82676-3

Download PDF Full Text: Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Tully, John P., 1965: Recommendations of the panel on sea surface temperature. Proceedings of the Conference on the feasibility of conducting oceanographic explorations from aircraft, manned orbital and lunar laboratories: Oceanography from space, Woods Hole, Mass , 24-28 August, 1964 117-118

Lowenstein, J..H.., 1992: Interpolating Hamiltonians for a stochastic-web map with quasicrystalline symmetry. A systematic Hamiltonian approximation scheme is developed for a stochastic-web map with fivefold quasicrystalline symmetry. Interpolating Hamiltonians are calculated up to tenth order in the control parameter a. The higher order Hamiltonians are...

Schütte, H.E., 1976: Treatment of invaginations in children. Nederlands Tijdschrift Voor Geneeskunde 120(44): 1882-1888

Yoshida, W.Y.; Bryan, P.J.; Baker, B.J.; McClintok, J.B., 1995: Pteroenone: a defensive metabolite of the abducted Antarctic pteropod Clione antarctica. Journal of Organic Chemistry. February 10; 603: 780-782

Saini, J.S.; Narula, A.S.; Khati, C.; Uberoi, H.S., 1996: Carbohydrate metabolic disturbances in hyperthyroidism. 25 hyperthyroid patients and 25 healthy volunteers were given an oral glucose tolerance test, and their glycosylated haemoglobin percentage was measured. Insulin secretory response was studied in 17 hyperthyroid patients and 10 controls. A varying...

SALVESEN, H.A., 1950: Alkali treatment of renal acidosis. Acta Medica Scandinavica. Supplementum 259: 75-89

Russell, V.M.; Schulten, G.G.M.; Roorda, F.A., 1980: Laboratory observations on the development of the rice moth Corcyra cephalonica Stainton Lepidoptera Galeriinae on millet and sorghum at 28degreeC and different relative humidities. Zeitschrift Fuer Angewandte Entomologie 89.5: 488-498

Iwata, O., 2001: Relationships between proenvironmental attitudes and concepts of nature. The author investigated relationships between proenvironmental attitudes and concepts of nature. Proenvironmental attitudes were measured on a 5-point scale containing 27 items. The author developed a 5-point scale containing 20 items to assess co...

Prada, J.A.; Ross, R.; Clark, K.E., 1992: Hypocalcemia and pregnancy-induced hypertension produced by maternal fasting. During pregnancy, maternal calcium needs increase as a result of increasing calcium requirements for fetal bone development. These needs have to be completely supplied by the mother via placental transfer. Several studies link low serum ionized ca...

Hendrickx, J.F.A.; D.R.dder, S.P.A.J.; Dehouwer, A.; Carette, R.; D.C.oman, S.; D.W.lf, A.M., 2015: In vitro performance of prefilled CO₂ absorbers with the Aisys®. Low flow anesthesia increases the use of CO2 absorbents, but independent data that compare canister life of the newest CO2 absorbents are scarce. Seven different pre-packed CO2 canisters were tested in vitro: Amsorb Plus, Spherasorb, LoFloSorb, Me...