EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization






Genes Chromosomes & Cancer 18(1): 59-65

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%), 8p (65%), 16q (54%), 17p (51%), 13q and 6q (37% each), and 1p (30%). The most frequent gains occurred on 8q (60%), 1q (58%), and 6p and 17q (33% each). In a few cases, sequence amplifications were detected that were mapped to bands 11q12, 12p11, 14q12, and 19q13.1. This study represents the first analysis of primary liver cancers by CGH, and it confirms the presence of previously known chromosomal aberrations in HCC and highlights new quantitative abnormalities and sequence amplifications. These findings should lead to the characterization of new loci involved in liver cancer pathogenesis.

Accession: 009310320

PMID: 8993981

DOI: 10.1016/s0165-4608(97)82676-3

Download PDF Full Text: Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization



Related references

Chromosomal alterations in human hepatocellular carcinoma cell lines detected by G-banding, comparative genomic hybridization and fluorescence in situ hybridization. Proceedings of the American Association for Cancer Research Annual Meeting 42: 66-67, March, 2001

Chromosomal imbalances detected by comparative genomic hybridization are associated with outcome of patients with hepatocellular carcinoma. Cancer 94(3): 746-751, February 1, 2002

Chromosomal Alterations in Hepatocellular Carcinoma Cell Lines Detected by Comparative Genomic Hybridization. Cancer Research and Treatment 34(3): 175-185, 2002

Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes & Cancer 29(2): 110-116, October, 2000

Pattern of chromosomal imbalances in non-B virus related hepatocellular carcinoma detected by comparative genomic hybridization. Cancer Genetics & Cytogenetics 127(1): 49-52, 2001

Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization. American Journal of Clinical Pathology 114(6): 867-874, 2001

Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma. Carcinogenesis 26(12): 2050-2057, 2005

Genomic characterization of prenatally detected chromosomal structural abnormalities using oligonucleotide array comparative genomic hybridization. American Journal of Medical Genetics. Part A 155a(7): 1605-1615, 2011

Chromosomal abnormalities in ependymomas detected by comparative genomic hybridization. Proceedings of the American Association for Cancer Research Annual Meeting 40: 537, March, 1999

Additional chromosomal abnormalities detected by array comparative genomic hybridization in AML. Medical Oncology 29(3): 2083-2087, 2013