EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization


, : Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes & Cancer 18(1): 59-65

Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%), 8p (65%), 16q (54%), 17p (51%), 13q and 6q (37% each), and 1p (30%). The most frequent gains occurred on 8q (60%), 1q (58%), and 6p and 17q (33% each). In a few cases, sequence amplifications were detected that were mapped to bands 11q12, 12p11, 14q12, and 19q13.1. This study represents the first analysis of primary liver cancers by CGH, and it confirms the presence of previously known chromosomal aberrations in HCC and highlights new quantitative abnormalities and sequence amplifications. These findings should lead to the characterization of new loci involved in liver cancer pathogenesis.

Accession: 009310320

PMID: 8993981

DOI: 10.1016/s0165-4608(97)82676-3

Download PDF Full Text: Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Kim, H.J.; Park, S.J.; Ha, M.J.on; Kim, H.C., 2001: Chromosomal alterations in human hepatocellular carcinoma cell lines detected by G-banding, comparative genomic hybridization and fluorescence in situ hybridization. Proceedings of the American Association for Cancer Research Annual Meeting 42: 66-67, March

Kusano, N.; Okita, K.; Shirahashi, H.; Harada, T.; Shiraishi, K.; Oga, A.; Kawauchi, S.; Furuya, T.; Sasaki, K., 2002: Chromosomal imbalances detected by comparative genomic hybridization are associated with outcome of patients with hepatocellular carcinoma. BACKGROUND: Biologic characteristics of tumors are greatly affected by genetic aberrations. However, to the authors' knowledge there is no study that shows that cytogenetic information is useful for estimating prognosis of patients with hepat...

Park, S.Jin.; Ha, M.Joon.; Kim, H.Chul.; Kim, H.Ju., 2002: Chromosomal Alterations in Hepatocellular Carcinoma Cell Lines Detected by Comparative Genomic Hybridization. There have only been a few cytogenetic studies of hepatocellular carcinoma (HCC), and so far, no consistent specific chromosomal abnormalities have been described. Here, we have used comparative genomic hybridization (CGH), a powerful molecular cy...

Guan, X.Y.an; Fang, Y.; Sham, J.S.T.; Kwong, D.L.W.; Zhang, Y.; Liang, Q.; Li, H.; Zhou, H.; Trent, J.M., 2000: Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and has a very poor prognosis. Fifty primary HCC cases have been analyzed in the present study to explore the association between genomic alteration in primary HCC and...

Collonge Rame, M.A.; Bresson Hadni, S.; Koch, S.; Carbillet, J.P.; Blagosklonova, O.; Mantion, G.; Miguet, J.P.; Heyd, B.; Bresson, J.L., 2001: Pattern of chromosomal imbalances in non-B virus related hepatocellular carcinoma detected by comparative genomic hybridization. Only limited data are available on comparative genomic hybridization (CGH) in hepatocellular carcinoma (HCC). They concern mainly B virus related HCC. Therefore, we used CGH to detect chromosomal imbalances in 16 non-B virus related HCC in alcohol...

Collonge-Rame, M.A.; Bresson-Hadni, S.; Koch, S.; Carbillet, J.P.; Blagosklonova, O.; Mantion, G.; Miguet, J.P.; Heyd, B.; Bresson, J.L., 2001: Pattern of chromosomal imbalances in non-B virus related hepatocellular carcinoma detected by comparative genomic hybridization. Only limited data are available on comparative genomic hybridization (CGH) in hepatocellular carcinoma (HCC). They concern mainly B virus related HCC. Therefore, we used CGH to detect chromosomal imbalances in 16 non-B virus related HCC in alcohol...

Wilkens, L.; Bredt, M.; Flemming, P.; Kubicka, S.; Klempnauer, J.; Kreipe, H., 2001: Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization. Fibrolamellar hepatocellular carcinoma (FLC) is a rare entity of hepatocellular carcinoma (HCC) not yet analyzed cytogenetically. By using comparative genomic hybridization (CGH), we looked for chromosome changes in 2 primary FLCs and a recurrent...

Patil, M.A.; Gütgemann, I.; Zhang, J.; Ho, C.; Cheung, S-Tim.; Ginzinger, D.; Li, R.; Dykema, K.J.; So, S.; Fan, S-Tat.; Kakar, S.; Furge, K.A.; Büttner, R.; Chen, X., 2005: Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide. We have previously characterized global gene expression patterns in HCC using microarrays. Here, we report the analysis of genomic DNA copy number among 49 HCC samples usin...

Li, P.; Pomianowski, P.; DiMaio, M.S.; Florio, J.R.; Rossi, M.R.; Xiang, B.; Xu, F.; Yang, H.; Geng, Q.; Xie, J.; Mahoney, M.J., 2011: Genomic characterization of prenatally detected chromosomal structural abnormalities using oligonucleotide array comparative genomic hybridization. Detection of chromosomal structural abnormalities using conventional cytogenetic methods poses a challenge for prenatal genetic counseling due to unpredictable clinical outcomes and risk of recurrence. Of the 1,726 prenatal cases in a 3-year perio...

Hirose, Y.; Kunwar, S.; Bollen, A.W.; James, D.; Berger, M.S.; Feuerstein, B.G., 1999: Chromosomal abnormalities in ependymomas detected by comparative genomic hybridization. Proceedings of the American Association for Cancer Research Annual Meeting 40: 537, March