Regenerating retinal fibers display error-free homing along undamaged normal fibers

Wilm, C.; Fritzsch, B.

Journal of Neurobiology 24(7): 898-902

1993


ISSN/ISBN: 0022-3034
PMID: 8228967
DOI: 10.1002/neu.480240703
Accession: 009316382

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Abstract
After crushing one optic nerve in a bony fish, retinal fibers regenerate to both tecta. Anterograde labelling indicates that the ipsilaterally regenerating fibers have a rather straight growth, apparently along the undamaged fibers of the contralateral retina. In contrast, the contralaterally regenerating fibers deviate widely from a straight course. Retrograde labelling shows a mirror-symmetric distribution of regenerated ipsilateral and resident contralateral ganglion cells in a comparable annulus. In contrast, ganglion cells in the regenerated contralateral retina show no topological order after comparable small Dil applications to the ventrolateral tectum. These data suggest that regenerating fibers can orient on the undisturbed, contralateral fibers.

Regenerating retinal fibers display error-free homing along undamaged normal fibers