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Release-activated Ca-2+ transport in neurons of frog sympathetic ganglia



Release-activated Ca-2+ transport in neurons of frog sympathetic ganglia



Neuron 19(2): 403-419



Frog sympathetic ganglion neurons exhibit a novel Ca-2+ uptake mechanism, release-activated calcium transport or RACT, which is manifest in both cytosolic and store (Ca-2+) signals as greatly accelerated Ca-2+ uptake after Ca-2+ release from internal stores. RACT is activated by Ca-2+ release but not by Ca-2+ entry and serves to selectively refill Ca-2+ stores after release. RACT lowers cytosolic (Ca-2+) with a rate constant about 1.6 times that of the SERCA pump with empty ER. RACT is thapsigargin-insensitive, was eliminated by ryanodine, but was not affected by blocking mitochondrial or plasma membrane Ca-2+ transport. A Ca-2+ flux model with RACT in the ER membrane reproduced the cytosolic and store (Ca-2+) responses to all stimuli.

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Accession: 009334184

Download citation: RISBibTeXText

PMID: 9292729

DOI: 10.1016/s0896-6273(00)80949-6


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