+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Renal abnormality of calcium handling in spontaneously hypertensive rats



Renal abnormality of calcium handling in spontaneously hypertensive rats



Kidney International. Suppl. 55: S166-S168



Hypercalciuria has been observed in human and experimental hypertension. The distal convoluted tubule (DCT) is the site of fine regulation for Ca-2+ excretion. We assessed the cellular factors responsible for Ca-2+ reabsorption in the DCT of spontaneously hypertensive rats (SHR). Vitamin D3 dependent Ca-binding protein 28k (CaBP-28k), a factor involved in Ca-2+ influx, and plasma membrane Ca ATPases (PMCA), a factor involved in Ca-2+ efflux, were studied in hypertensive 16-week-old SHR and normotensive Wistar-Kyoto rats (WKY). mRNA levels for CaBP-28k, PMCA 2 and PMCA 4 were not different in the two strains. However, CaBP-28k protein was more abundant, and PMCA protein was less abundant in SHR than in WKY. PMCA antibody recognized only DCT in the two strains. In conclusion, decreased PMCA in DCT may be responsible for the hypercalciuria in SHR.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 009336264

Download citation: RISBibTeXText

PMID: 8743545


Related references

Long-term renal handling of sodium and calcium in spontaneously hypertensive rats. Renal Physiology and Biochemistry 15(2): 83-88, 1992

Role of the renal sympathetic nerves in renal sodium/potassium handling and renal damage in spontaneously hypertensive rats. Experimental and Therapeutic Medicine 12(4): 2547-2553, 2016

Renal concentrating ability and calcium load handling in the spontaneously hypertensive rat. Ohio Journal of Science 80(2): 77-82, 1980

Platelet calcium handling in spontaneously hypertensive rats and in three strains of normotensive rats. Journal of Hypertension 11(5): 509-514, 1993

Abnormal calcium handling by platelets of spontaneously hypertensive rats. Hypertension 15(6 Pt 1): 606-611, 1990

Genetically altered brain amino acid metabolism in spontaneously hypertensive rats: a study by using young spontaneously hypertensive rats and renal hypertensive rats. Clinical and Experimental Hypertension. Part A, Theory and Practice 12(7): 1191-1201, 1990

Renal calcium and phosphate handling in the spontaneously hypertensive rat and normotensive Wistar-Kyoto control rat. Progress in Clinical and Biological Research 168: 369-374, 1984

Early altered renal sodium handling determined by lithium clearance in spontaneously hypertensive rats (SHR): role of renal nerves. Life Sciences 76(16): 1805-1815, 2005

Altered renal sodium handling in spontaneously hypertensive rats (SHR) after hypertonic saline intracerebroventricular injection: role of renal nerves. Life Sciences 79(17): 1666-1673, 2006

Increased calcium handling properties in the femoral arteries of spontaneously hypertensive rats. Japanese Journal of Pharmacology 40(Suppl.): 100P, 1986

Effect of clonidine on renal sodium handling in spontaneously hypertensive rats. Journal of Pharmacological Sciences 119(2): 122-130, 2012

Reduced calcium binding capacity is an intrinsic abnormality of red blood cell membrane in spontaneously hypertensive rats. American Journal of Hypertension 3(7): 570-572, 1990

Abnormal calcium handling by isolated cardiac plasma membrane from spontaneously hypertensive rats. Clinical Science 61(Suppl. 7): 45s-48s, 1981

Effect of 1 25 dihydroxyvitamin d 3 on calcium handling in proximal duodenal enterocytes from spontaneously hypertensive rats shr. Kidney International 33(1): 305, 1988

Abnormal calcium handling in vascular smooth muscle cells of spontaneously hypertensive rats. Journal of Hypertension 8(4): 369-375, 1990