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Retrovirus-induced lymphoproliferative disease in mice: role of humoral immunity in perinatally exposed mice



Retrovirus-induced lymphoproliferative disease in mice: role of humoral immunity in perinatally exposed mice



Immunobiology 194(4-5): 390-402



The mice born to female mice infected with LP-BM5 MuLV, the etiologic agent for lymphoproliferative disease and nursed for 4-6 weeks by them were less susceptible upon reinfection by i.v. transfusion of blood or plasma from infected donors with fully developed disease. Sera of 7 week or older perinatally exposed mice were capable of a complete in vitro neutralization of virus in plasma or blood from mice with fully developed disease. In contrast, sera from 3-week old perinatally exposed mice were ineffective. The neutralizing ability of the sera was drastically reduced or abrogated after their absorption with anti-mouse IgM. These observations are consistent with the notion that perinatally exposure results ina moderate form of the disease of the offspring. This perinatal infection is followed by a production of neutralizing antibodies of predominantly the IgM class that significantly alters the course of the lymphoproliferative disease and, in some instances, even prevents its development.

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Accession: 009354896

Download citation: RISBibTeXText

PMID: 8749232

DOI: 10.1016/s0171-2985(11)80106-3


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