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Reversible acute renal failure induced by losartan in a renal transplant recipient

Reversible acute renal failure induced by losartan in a renal transplant recipient

Postgraduate Medical Journal 73(856): 105-107

A 56-year-old man who received a live-related renal transplant in 1988 was started in 1995 on the selective angiotensin II antagonist losartan (Dupont - Merke) to treat worsening hypertension. Two months later because of pulmonary oedema, loop diuretics were started. Within two weeks, serum creatinine had increased from 245 to 571 mu-mol/l, and the patient became oliguric. A systolic bruit was noted over the graft. Renal angiography showed a 90% stenosis of the transplant renal artery. Losartan was withdrawn, with prompt improvement in renal function. A successful percutaneous translational angioplasty performed a few days later resulted in further improvement in renal function accompanied by a significant diuresis.

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Accession: 009356074

Download citation: RISBibTeXText

PMID: 9122087

DOI: 10.1136/pgmj.73.856.105

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