+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Reversible renal failure due to the antiphospholipid antibody syndrome, pre-eclampsia and renal thrombotic microangiopathy

Reversible renal failure due to the antiphospholipid antibody syndrome, pre-eclampsia and renal thrombotic microangiopathy

Clinical Nephrology 44(4): 271-273

A 27-year-old Caucasian female, with a past history of recurrent spontaneous abortions, was admitted with pre-eclampsia at 26 weeks' gestation during her sixth pregnancy. She was previously known to have antiphospholipid antibodies since her fifth abortion, but had no clinical or serological evidence of systemic lupus erythematosus. A small-for-dates infant was delivered by emergency Caesarean section at 27 weeks for poor placental blood flow and fetal distress. She was transferred to the renal unit on the sixth post partum day with pulmonary edema, hypertension, disseminated intravascular coagulation and acute renal failure. Renal biopsy showed lesions compatible with thrombotic microangiopathy with diffuse glomerular necrosis. She was plasma exchanged and remained dialysis dependent for 7 months. Antiphospholipid antibodies were present in high titres and were the presumed cause of her acute renal failure. The patient now has stable renal function with a creatinine clearance of 30 ml/min for over two years. The late recovery of renal function is unique in the above circumstances.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 009356448

Download citation: RISBibTeXText

PMID: 8575129

Related references

A case of primary antiphospholipid antibody syndrome with acute renal failure showing thrombotic microangiopathy. American Journal of Nephrology 19(5): 594-598, 1999

A 3-year follow-up of a patient with acute renal failure caused by thrombotic microangiopathy related to antiphospholipid syndrome: case report. Lupus 26(7): 777-782, 2017

Antiphospholipid syndrome and renal thrombotic microangiopathy. JN Journal of Nephrology 8(3): 123-125, 1995

De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy. American Journal of Kidney Diseases 41(2): 471-479, 2003

Renal thrombotic microangiopathy and antiphospholipid syndrome nephropathy in a patient with lupus nephritis. Nihon Jinzo Gakkai Shi 58(1): 45-54, 2016

Primary antiphospholipid syndrome paps associated with renal thrombotic microangiopathy tma report of 4 cases. Journal of the American Society of Nephrology 2(3): 267, 1991

Renal thrombotic microangiopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome. American Journal of Kidney Diseases 20(2): 150-158, 1992

Thrombotic microangiopathy and poor renal outcome in lupus patients with or without antiphospholipid syndrome. Clinical and Experimental Rheumatology 33(4): 503-508, 2015

Catastrophic antiphospholipid syndrome presenting with renal thrombotic microangiopathy and diffuse proliferative glomerulonephritis. Clinical and Experimental Rheumatology 24(1): 110, 2006

Association of thrombotic microangiopathy and intimal hyperplasia with bleeding post-renal biopsy in antiphospholipid antibody-positive patients. Arthritis Care and Research 66(5): 725-731, 2014

Thrombotic microangiopathy with reversible acute renal failure in a cardiac transplant recipient under cyclosporin. Clinical Nephrology 34(5): 237-238, 1990

Renal thrombotic microangiopathy in a patient with rheumatoid arthritis and antiphospholipid syndrome: successful treatment with cyclophosphamide pulse therapy and anticoagulant. Internal Medicine 33(8): 484-487, 1994

Thrombotic microangiopathy and the antiphospholipid antibody syndrome. Journal of Rheumatology 18(12): 1916-1918, 1991

Catastrophic antiphospholipid antibody syndrome in a child with thrombotic microangiopathy. Indian Journal of Nephrology 22(4): 310-313, 2012

Acute renal failure in a renal allograft: an unusual infectious cause of thrombotic microangiopathy. American Journal of Kidney Diseases 46(1): 159-162, 2005