Role of endothelin-1 in ischemic acute renal failure in rats

Tanaka, Y.; Ohtsubo, Y.; Furukawa, M.

Pharmacy and Pharmacology Communications 4(6): 297-300

1998


DOI: 10.1111/j.2042-7158.1998.tb00699.x
Accession: 009366754

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Abstract
The role of endothelin-1 in ischemic acute renal failure in rats is described. After 45 min of ischemia, mean blood pressure was increased by 11% and renal blood flow (RBF) and renal surface blood flow (RSBF) rates were reduced by about 30% resulting in a 70% increase in renal vascular resistance (RVR) compared with non-ischemic control rats. Higher levels of endothelin-1 were also found in the kidneys and plasma of ischemic rats. Endothelin-1-induced ischemia seems to play a significant role in the pathogenesis of acute renal failure. During reperfusion, injection of endothelin-1 (0.1-0.3 nmol kg-1) into post-ischemic rats did not affect RBF, RSBF or RVR. However, injection of the alpha-stimulant, 1-phenylephrine (1-10 mug kg-1), dose-dependently reduced RBF and RSBF, regardless of whether renal ischemia had occurred. The endothelin-1 insensitivity of post-ischemic rats may be due to inactivation of the vasocontractile systems or activation of the vasodilative systems.

Role of endothelin-1 in ischemic acute renal failure in rats