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Roles of the periplasmic domain of Escherichia coli FtsH (HflB) in protein interactions and activity modulation



Roles of the periplasmic domain of Escherichia coli FtsH (HflB) in protein interactions and activity modulation



Journal of Biological Chemistry 273(35): 22326-22333



FtsH is a membrane-bound and ATP-dependent protease of Escherichia coli, known to degrade SecY, a membrane protein for protein translocation, and CII, a soluble transcription factor for lysis/lysogeny decision of phage lambda. FtsH forms a homo-oligomeric complex as well as a hetero-oligomeric complex with HflKC, a putative modulator of FtsH. Although FtsH has a small periplasmic region, HflKC is mostly exposed to the periplasmic space.

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Accession: 009372131

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PMID: 9712851


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