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Selection of a precore mutant of hepatitis B virus and reactivation of chronic hepatitis B acquired in childhood



Selection of a precore mutant of hepatitis B virus and reactivation of chronic hepatitis B acquired in childhood



Journal of Pediatrics 123(4): 583-585



A 14-year-old girl with chronic hepatitis B had seroconversion from hepatitis B e antigen to antibody and achieved biochemical remission after 2 years. The disease reactivated 9 years later when a precore mutant had become the prevalent hepatitis B virus strain in serum. These results suggest that selection of a precore mutant might induce reactivation during adult life of chronic hepatitis B acquired in childhood, thus worsening the prognosis.

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Accession: 009390475

Download citation: RISBibTeXText

PMID: 8410512

DOI: 10.1016/s0022-3476(05)80956-4


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