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Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells

Terada, Y.; Tomita, K.; Homma, M.K.; Nonoguchi, H.; Yang, T.; Yamada, T.; Yuasa, Y.; Krebs, E.G.; Sasaki, S.; Marumo, F.

Journal of Biological Chemistry 269(49): 31296-31301

1994


ISSN/ISBN: 0021-9258
PMID: 7527042
Accession: 009400816

In the renal medulla during antidiuresis, the extracellular fluid becomes hyperosmotic. Madin-Darby canine kidney (MDCK) epithelial cells adapt in hyperosmotic conditions and serve as a useful tissue culture model for cellular responses to hyperosmolality.

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