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Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men



Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men



Clinical Endocrinology 44(6): 659-664



Objective: Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins. one of which is insulin-like growth factor-binding protein-I (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men. Design and Patients: The associations between the serum levels of IGF-I and IGFBP-1 on one hand, and testosterone and SHBG on the other were investigated in 38 normal healthy young and middle-aged men. Results: Serum levels of IGF-I decreased both with increasing age (r=-0.66, P lt 0.001) and increasing SHBG levels (r = -0.46, P = 0.002), but increased with increasing free testosterone (f-testosterone) (r=0.42, P=0.005). These associations remained after mutual simultaneous adjustments in a multiple regression analysis. IGFBP-I did not display any significant univariate correlation with age (r=-0.25, P=0.06) or SHBG (r=0.18, P=0.14), but showed a significant positive correlation with both f-testosterone (r=0.42, P = 0.004), and total testosterone (t-testosterone) (r=0.39, P=0.008). In a multiple regression analysis IGFBP-1 was positively correlated with both SHBG and f-testosterone, but not with t-testosterone. Conclusion: The present study suggests that among healthy young and middle-aged men, there is an association between serum levels of free-testosterone and SHBG on the one hand, and serum IGF-I and IGFBP-1 on the other.

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Accession: 009405830

Download citation: RISBibTeXText

PMID: 8801037

DOI: 10.1046/j.1365-2265.1996.731552.x


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